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首页> 外文期刊>Archives of General Psychiatry >Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder.
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Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder.

机译：海马的磁共振成像创伤后应激障碍的分支学科。

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CONTEXT: Most neuroimaging studies of posttraumatic stress disorder (PTSD) have focused on potential abnormalities in the whole hippocampus, but the subfields of this structure, which have distinctive histological characteristics and specialized functions, have not been investigated. Studies of individual subfields may clarify the role of the hippocampus in PTSD. OBJECTIVE: To determine if PTSD is associated with structural alterations in specific subfields of the hippocampus. DESIGN: Case-control study. PARTICIPANTS: A total of 17 male veterans with combat trauma and PTSD (mean [SD] age, 41 [12] years) and 19 age-matched male veterans without PTSD who were recruited from the outpatient mental health clinic of the San Francisco Veterans Affairs Medical Center and by advertising in the community. INTERVENTIONS: High-resolution magnetic resonance imaging at 4 T. MAIN OUTCOME MEASURE: Volumes of hippocampal subfields. RESULTS: Posttraumatic stress disorder was associated with 11.4% (1.5%) (P = .02) smaller mean (SD) cornu ammonis 3 (CA3)/dentate gyrus subfield volumes, irrespective of age-related alterations, whereas other subfields were spared. Age was associated with reduced volume of the CA1 subfield (P = .03). Total hippocampal volume was also reduced in PTSD by a mean (SD) of 6.5% (0.6%) but, related to both PTSD (P = .05) and age (P = .01), was consistent with the measurements in the subfields. CONCLUSIONS: The findings indicate for the first time in humans that PTSD is associated with selective volume loss of the CA3/dentate gyrus subfields, consistent with animal studies, implying that chronic stress suppresses neurogenesis and dendritic branching in these structures.
机译：背景:大多数的神经影像学研究创伤后应激障碍(PTSD)集中在整个潜在的异常海马,但这种结构的分支学科,具有独特的组织学特点和特殊功能,没有被调查。子字段可能澄清海马的作用在创伤后应激障碍。与结构的改变有关海马体的特定领域。病例对照研究。男性与战争创伤和创伤后应激障碍的退伍军人(的意思(SD)年龄、41[12]年)和19的同龄男性退伍军人没有PTSD的招募圣的门诊精神健康诊所旧金山退伍军人医疗中心在社区广告。高分辨率磁共振成像在4主要结果测量:海马的体积分支学科。与11.4% (1.5%)(P = .02点)小的意思(SD)角ammonis 3 (CA3) /齿状回分区卷,不管与年龄相关的变化,而其他分支学科幸免于难。体积的CA1子域(P = . 03)。海马体积也减少在创伤后应激障碍意味着(SD)的6.5%(0.6%),但有关创伤后应激障碍(P = . 05)和年龄(P = . 01),是一致的与测量等领域。结论:研究结果表明第一在人类与创伤后应激障碍选择性的体积损失CA3 /齿状回分支学科,与动物研究一致,这意味着长期的压力会抑制神经发生,在这些树突分支结构。

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