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首页> 外文期刊>Archives of General Psychiatry >Decreased hippocampal volume in healthy girls at risk of depression.
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Decreased hippocampal volume in healthy girls at risk of depression.

机译：减少海马体积在健康的女孩抑郁症的风险。

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CONTEXT: Researchers have documented that the hippocampus is smaller in individuals with depression than in those without. The temporal or causal association of this reduction in hippocampal volume in depression, however, is not known. OBJECTIVE: To test the hypothesis that reduced hippocampal volume precedes and therefore may be implicated in the onset of depression. DESIGN: We used magnetic resonance imaging to examine brain structure volume in individuals at high and low familial risk of depression. Anatomic images from magnetic resonance imaging were analyzed using both whole-brain voxel-based morphometry and manual tracing of the bilateral hippocampus. SETTING: A research university. PARTICIPANTS: Fifty-five girls aged between 9 and 15 years: 23 daughters of mothers with recurrent episodes of depression in the daughter's lifetime (high risk) and 32 age-matched daughters of mothers with no history of psychopathology (low risk). None of the girls had any past or current Axis I psychopathology. MAIN OUTCOME MEASURES: Group differences in voxel-based morphometry brain matter density estimates and traced hippocampal volume. RESULTS: Voxel-based morphometry analyses indicated that individuals at high risk of depression had significantly less gray matter density in clusters in the bilateral hippocampus (P < .001) than low-risk participants. Tracing yielded a volumetric reduction in the left hippocampus in the high-risk participants (P < .05). CONCLUSIONS: Compared with individuals at low familial risk of the development of depression, high-risk individuals have reduced hippocampal volume, indicating that neuroanatomic anomalies associated with depression may precede the onset of a depressive episode and influence the development and course of this disorder.
机译：背景:研究人员记录,海马体是较小的患者比那些没有抑郁症。因果联系的减少海马体积的抑郁,然而,不是已知的。海马体积之前,因此减少可能与抑郁症的发病。设计:我们使用磁共振成像在个人在研究大脑结构体积高、低家族性抑郁症的风险。解剖图像从磁共振成像分析了使用全脑分布形态测量学和手动跟踪两国海马体。参与者:55女孩9岁至与复发15年:23岁女儿的母亲抑郁发作的女儿的一生(高风险)和32的同龄的女子母亲没有精神病理学(低的历史风险)。轴我精神病理学。组的差异分布形态测量学大脑物质密度估计和跟踪海马体积。形态测量学分析表明,个人在高抑郁的风险已经大大减少灰质密度在两国的集群海马体(P <比低风险的措施)参与者。减少在左侧海马高风险的参与者(P < . 05)。相比之下,个人家庭的风险较低抑郁的发展,高风险人减少了海马体积,表明解剖异常与抑郁可能爆发之前抑郁发作的影响这种疾病的发展和课程。

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