Severe mental disorders in offspring with 2 psychiatrically ill parents.

Gottesman II; Laursen TM; Bertelsen

摘要

BACKGROUND: Studies of couples of psychiatric patients with children allow us to calculate the effects of double predispositions on morbid risk in the offspring, which is of interest for molecular genetic research and for genetic counseling. OBJECTIVE: To determine the risks in offspring of receiving a diagnosis of schizophrenia, bipolar disorder, unipolar depressive disorder, or any diagnosis from parents who both have received a diagnosis of schizophrenia or bipolar disorder. DESIGN: National register-based cohort study. SETTING: Denmark. PARTICIPANTS: A population-based cohort of 2.7 million persons born in Denmark, alive in 1968 or born later than 1968, with a register link to their mother and father and aged 10 years or older in 2007. MAIN OUTCOME MEASURE: Risk of schizophrenia or bipolar disorder, calculated as cumulative incidences by age 52 years. RESULTS: The risk of schizophrenia in 270 offspring of 196 parent couples who were both admitted to a psychiatric facility with a diagnosis of schizophrenia was 27.3% (increasing to 39.2% when schizophrenia-related disorders were included) compared with 7.0% in 13 878 offspring from 8006 couples with only 1 parent ever admitted for schizophrenia and 0.86% in 2 239 551 offspring of 1 080 030 couples with neither parent ever admitted. The risk of bipolar disorder was 24.9% in 146 offspring of 83 parent couples who were ever admitted with bipolar disorder (increasing to 36.0% when unipolar depressive disorder was included) compared with 4.4% in 23 152 offspring from 11 995 couples with only 1 parent ever admitted and 0.48% in 2 239 553 offspring of 1 080 030 couples with neither parent ever admitted. Risks of schizophrenia and bipolar disorder in offspring of couples with 1 parent with schizophrenia and the other with bipolar disorder were 15.6% and 11.7%, respectively. The maximal risks of any psychiatric disorders in the offspring of parents both with schizophrenia or both with bipolar disorder were 67.5% and 44.2%, respectively. CONCLUSIONS: Derived risks may be informative for counseling. Patterns of transmission may support evolving assumptions about genetic overlap for traditional categories.

机译：背景:研究精神病的夫妇孩子让我们来计算患者双重倾向对病态的影响的风险的后代,这是感兴趣的分子遗传研究和遗传咨询。的后代接受诊断精神分裂症、双相情感障碍,单极抑郁症,或任何诊断父母都有收到了诊断精神分裂症和双相情感障碍。国家基于寄存器的队列研究。丹麦。在丹麦出生的270万人的,还活着1968出生于1968年以后的,登记链接到他们的母亲和父亲和老了10岁在2007年以上。精神分裂症和双相情感障碍、计算累积发生率52岁。在196年270后代患精神分裂症的风险父母的夫妻都是承认的精神病学的诊断设备当精神分裂症(增加27.3%到39.2%schizophrenia-related障碍包括)相比之下,13 878后代从8006年的7.0%夫妻只有1家长承认过精神分裂症和0.86% 2 239 551的后代1 080 030对夫妇没有父母承认。146年83父夫妇的后代承认与双相情感障碍(增加单极抑郁障碍时的36.0%152年23)比例为4.4%的后代从11 995对夫妇只有1父母承认和0.48% 2 239 553 1的后代080 030对夫妇没有父母承认。障碍与1父母夫妇的后代精神分裂症和双相障碍分别为15.6%和11.7%,分别。最大的任何精神疾病的风险孩子的父母都患有精神分裂症或双相情感障碍患者分别为67.5%和44.2%,分别。信息咨询。传播可能支持进化的假设关于基因重叠对传统类别。

Severe mental disorders in offspring with 2 psychiatrically ill parents.

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