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首页> 外文期刊>Archives of general psychiatry. >Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.
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Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.

机译：童年的病因及临床特征精神症状:结果从出生队列。

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CONTEXT: It has been reported that childhood psychotic symptoms are common in the general population and may signal neurodevelopmental processes that lead to schizophrenia. However, it is not clear whether these symptoms are associated with the same extensive risk factors established for adult schizophrenia. OBJECTIVE: To examine the construct validity of children's self-reported psychotic symptoms by testing whether these symptoms share the risk factors and clinical features of adult schizophrenia. DESIGN: Prospective, longitudinal cohort study of a nationally representative birth cohort in Great Britain. PARTICIPANTS: A total of 2232 twelve-year-old children followed up since age 5 years (retention, 96%). Main Outcome Measure Children's self-reported hallucinations and delusions. RESULTS: Children's psychotic symptoms are familial and heritable and are associated with social risk factors (eg, urbanicity); cognitive impairments at age 5; home-rearing risk factors (eg, maternal expressed emotion); behavioral, emotional, and educational problems at age 5; and comorbid conditions, including self-harm. CONCLUSIONS: The results provide a comprehensive picture of the construct validity of children's self-reported psychotic symptoms. For researchers, the findings indicate that children who have psychotic symptoms can be recruited for neuroscience research to determine the pathogenesis of schizophrenia. For clinicians, the findings indicate that psychotic symptoms in childhood are often a marker of an impaired developmental process and should be actively assessed.
机译：背景:据报道,童年精神病症状是常见的人口和神经发育可能信号过程会导致精神分裂症。还不清楚这些症状吗与相同的广泛的风险因素建立了成人精神分裂症。检查儿童的建构效度自我报告的精神病症状通过测试这些症状是否共享和危险因素成人精神分裂症的临床特征。前瞻性纵向队列研究全国代表性出生队列的英国。12岁的孩子5岁以来的跟进年(保留96%)。孩子们的自我报告的幻觉和错觉。家族性和遗传有关吗与社会风险因素(例如,城市化程度);认知障碍5岁;因素(如母亲的情感表达);行为、情感、和教育问题5岁;自残。全面的建构效度孩子的自我报告的精神病症状。对于研究人员,研究结果表明有精神病症状的孩子招募了神经科学的研究来确定精神分裂症的发病机理。临床医生、研究结果表明精神病症状在儿童时期经常的一个标志受损的发育过程和应积极评估。

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