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首页> 外文期刊>Archives of general psychiatry. >Posttraumatic stress disorder and risk of dementia among US veterans.
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Posttraumatic stress disorder and risk of dementia among US veterans.

机译：创伤后应激障碍和痴呆的风险在美国退伍军人。

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CONTEXT: Posttraumatic stress disorder (PTSD) is highly prevalent among US veterans because of combat and may impair cognition. OBJECTIVE: To determine whether PTSD is associated with the risk of developing dementia among older US veterans receiving treatment in the Department of Veterans Affairs medical centers. DESIGN: A stratified, retrospective cohort study conducted using the Department of Veterans Affairs National Patient Care Database. SETTING: Department of Veterans Affairs medical centers in the United States. PARTICIPANTS: A total of 181 093 veterans 55 years or older without dementia from fiscal years 1997 through 2000 (53 155 veterans with and 127 938 veterans without PTSD). MAIN OUTCOME MEASURES: During the follow-up period between October 1, 2000, and December 31, 2007, 31 107 (17.2%) veterans were ascertained to have newly diagnosed dementia according to International Classification of Diseases, Ninth Revision, Clinical Modification codes. RESULTS: The mean baseline age of the veterans was 68.8 years, and 174 806 (96.5%) were men. Veterans with PTSD had a 7-year cumulative incident dementia rate of 10.6%, whereas those without had a rate of 6.6% (P < .001). With age as the time scale, Cox proportional hazards models indicated that patients with PTSD were more than twice as likely to develop incident dementia compared with those without PTSD (hazard ratio, 2.31; 95% confidence interval, 2.24-2.39). After multivariable adjustment, patients with PTSD were still more likely to develop dementia (hazard ratio, 1.77; 95% confidence interval, 1.70-1.85). Results were similar when we excluded those with a history of head injury, substance abuse, or clinical depression. CONCLUSIONS: In a predominantly male veteran cohort, those diagnosed as having PTSD were at a nearly 2-fold-higher risk of developing dementia compared with those without PTSD. Mechanisms linking these important disorders need to be identified with the hope of finding ways to reduce the increased risk of dementia associated with PTSD.
机译：背景:创伤后应激障碍(PTSD)在我们的退伍军人,因为非常普遍战斗,可能影响认知。确定是否与创伤后应激障碍美国老年人当中患痴呆症的风险退伍军人在美国接受治疗退伍军人医疗中心。分层,回顾性队列研究使用退伍军人事务部的国家病人护理的数据库。退伍军人医疗中心在美国州。从财政55岁以上无痴呆1997年到2000年(53 155退伍军人和没有PTSD) 127 938退伍军人。措施:在随访期间之间2000年10月1日,2007年12月31日,31日107年(17.2%)退伍军人被确定新根据国际诊断痴呆疾病分类,第九次修订,临床修改代码。基线退伍军人的年龄是68.8岁,174 806(96.5%)人。7年累计事件痴呆率10.6%,而那些没有6.6%的速度(P <措施)。比例风险模型表示创伤后应激障碍患者的两倍以上事件痴呆与发展没有PTSD(风险比,2.31;区间,2.24 - -2.39)。调整,PTSD患者还更多可能患老年痴呆症(风险比,1.77;95%置信区间,1.70 - -1.85)。当我们排除了那些历史的相似头部受伤、物质滥用或临床抑郁症。经验丰富的群体,这些诊断出患有创伤后应激障碍在近2-fold-higher的风险痴呆与那些没有创伤后应激障碍。机制将这些重要的障碍所需要的是希望找到方法来识别减少老年痴呆症的风险增加相关创伤后应激障碍。

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