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首页> 外文期刊>Archives of general psychiatry. >Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia.
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Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia.

机译：但幸免精度和减少能力维护工作记忆表征的精神分裂症。

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CONTEXT: Working memory deficits are considered a core feature of schizophrenia. Several recent integrative articles have offered mechanistic computational and neurobiological models of the origins of this cognitive deficit. OBJECTIVE: To test predictions of these models using a new experimental paradigm from the basic science literature that makes it possible to determine whether patients with schizophrenia show (1) deficits in working memory storage capacity, (2) deficits in the precision of working memory representations, and (3) an amplification of these deficits as the retention interval increases. DESIGN: Case-control design. All subjects performed a color working memory test in which they were asked to recall 3 or 4 items after a 1- or 4-second delay. All subjects also received a standard measure of intelligence and the Matrics Consensus Cognitive Battery. SETTING: A tertiary care research outpatient clinic. Patients A total of 31 clinically stable patients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 26 healthy volunteers participated. The 2 groups were similar in age, sex, and ethnicity distribution. MAIN OUTCOME MEASURES: (1) The number of items stored in working memory and (2) the precision of the working memory representations. RESULTS: Patients showed a clear reduction in the number of items stored in working memory. Patients did not differ from controls in the precision of their working memory representations. There was no evidence of delay-related amplification of impairment in either capacity or precision. CONCLUSIONS: Patients do not show the type of imprecision or delay-dependent amplification of impairment that is predicted on the basis of current models of the neurobiology of schizophrenia. The models need to be revised to account for a pure reduction in the number of items that patients are able to store in working memory.
机译：背景:工作记忆缺陷被认为是精神分裂症的核心功能。综合文章提供了机械的计算和神经生物学模型的起源的认知赤字。使用一个新的测试这些模型的预测从基础科学实验范式文学可以确定精神分裂症患者是否显示(1)赤字在工作记忆存储能力,(2)赤字在工作记忆的精度表示,(3)的放大这些赤字保持间隔增加。工作记忆测试对象进行了颜色他们被要求回忆3或4物品吗后1 - 4秒延迟。收到了情报和的标准衡量电池矩阵共识的认知。三级护理研究门诊。患者共有31个临床稳定的患者dsm - iv诊断精神分裂症或分裂情感性障碍和26健康志愿者参与。相似的年龄、性别和种族分布。主要结果测量:(1)商品的数量储存在工作记忆和(2)的精度工作记忆表征。病人表现出明显的数量减少的物品储存在工作记忆。没有不同于控制的精度他们的工作记忆表征。没有证据表明delay-related放大损伤能力或精度。结论:患者不显示的类型不精确或时滞相关的放大预测的基础上的障碍当前模型的神经生物学精神分裂症。占一个纯粹的数量的减少项病人能够存储在工作内存。

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