Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

Cheng Wan-Min; Lu Xi; Shi JingLiu Lei

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Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

机译：选择性自然亲核的修改残留在肽和蛋白质arylpalladium复合物

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Transition metal-mediated modification of peptides and proteins is emerging as a powerful method for their selective functionalization and bioconjugation, particularly for native peptides and proteins bearing no unnatural bioorthogonal handles. The modified peptides and proteins are useful synthetic reagents needed in both biochemical and biophysical studies, as well as in pharmaceutical research. This mini-review surveys recent developments of regio- and chemoselective arylation reactions of the natural nucleophilic residues within unprotected peptides and proteins, promoted by arylpalladium complexes. These reactions exhibited high selectivities and excellent biocompatibility, proceeded under mild reaction conditions, and have a wide range of applications. They exemplify the advantages and potential of organometallic palladium complexes in bioconjugation, and are expected to inspire future studies on transition metal-mediated biocompatible modification reactions.

机译：过渡metal-mediated修改肽和蛋白质正在成为一个强大的方法他们的选择性功能化和bioconjugation,特别是对于原生肽和蛋白质bioorthogonal轴承没有不自然句柄。有用的合成试剂需要在两种生物化学和生物物理研究,以及在医药研究。调查最近的事态发展的地区,chemoselective芳基化反应的自然在无保护肽亲核残留物和蛋白质,由arylpalladium提升复合物。选择性和良好的生物相容性,在温和的反应条件下进行有广泛的应用。有机金属的优势和潜力在bioconjugation钯配合物,将激励未来研究过渡metal-mediated生物相容性的改性反应。

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来源
《Organic Chemistry Frontiers》 |2018年第21期|3186-3193|共8页
作者
Cheng Wan-Min; Lu Xi; Shi JingLiu Lei;
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作者单位

Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Urban Pollutant Convers, Anhui Prov Key Lab Biomass Clean Energy,iChEM, Hefei 230026, Anhui, Peoples R China;

Tsinghua Univ, Dept Chem, Tsinghua Peking Ctr Life Sci, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China;

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原文格式 PDF
正文语种英语
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关键词
Proteins; transition metal; peptides and proteinsREACTIONPeptides;

机译：蛋白质、过渡金属、肽和proteinsREACTIONPeptides;

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Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

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