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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Glucose-powered pulsatile release
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Glucose-powered pulsatile release

机译：Glucose-powered脉动的释放

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Pulsatile release is required for many drugs from hormones to vaccines, but automating this release typically requires elaborate pumping systems with electronic controls and transcutaneous catheters. This paper describes a materials-based approach to this functionality, using a combination of composite polymer membranes to provide discrete pulses of drug at preprogrammed intervals using only a static concentration of glucose in water. Drug is encapsulated in acid-sensitive polymer membranes. Enzymes which convert glucose to acid are immobilized in other polymer membranes, along with sacrificial acid scavengers. These membranes are stacked alternately into a polymer laminate and sealed around the bottom and edges. Glucose diffuses steadily into the top membrane and is converted to acid. This acid is consumed by the scavenger until the scavenger is exhausted, at which point it triggers the acid-sensitive drug membrane below. That membrane swells and delaminates from the stack, releasing its payload, and the process repeats, potentially with different drugs in each layer and different preprogrammed delay times between each dose. This paper provides the first experimental demonstration of such a system, characterizes its components, models the system computationally, and provides basic design rubrics for further development. (C) 2015 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
机译：跳动的释放需要许多药物激素疫苗,但自动化这个版本通常需要复杂泵系统电子控制和经皮的导管。本文描述了一个材料的方法这个功能,使用的组合复合聚合物膜提供离散脉冲预排程序的间隔使用的药物只有一个静态的浓度葡萄糖水。药物是封装在acid-sensitive聚合物膜。在其他聚合物膜固定化,一起吗与献祭酸食腐动物。交替堆叠成聚合物层压板吗和密封底和边。逐步扩散到膜和顶部转化为酸。清道夫,直到筋疲力尽,清道夫这一点它触发acid-sensitive毒品吗下面的膜。脱层的堆栈,释放它有效载荷,这个过程重复,有可能在每一层不同的药物和不同每个剂量之间的预排程序的延迟时间。论文提供了第一个实验这样一个系统的演示,是它的特点组件,系统计算模型,并进一步提供基本的设计题目发展。工程师。保留。

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