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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Parametric analysis of homogeneous and heterogeneous nucleation in subcritical CO2-mediated antisolvent crystallization
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Parametric analysis of homogeneous and heterogeneous nucleation in subcritical CO2-mediated antisolvent crystallization

机译：参数分析均匀和在亚临界异相成核CO2-mediated antisolvent结晶

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摘要

The present work investigates the tunability of antisolvency effect of subcritical carbon dioxide (CO2), in a solution of cholesterol in acetone, which facilitates high and rapid supersaturation needed for producing cholesterol micro -particles. A thermodynamic analysis is proposed for selection of operating conditions that result in high solid solute supersaturation. This is further coupled to a computational analysis of homogeneous and heterogeneous nucleation, and crystal growth kinetics. A numerical strategy has been evolved and for verifying its consistency the predicted particle size has been compared with that obtained experimentally. In addition, the effects of pressure (60-70 bar), temperature (291-303 K), initial solute concentration (90-100%), specific dissolution rate of CO2 (0.095-6.0 min(-1)), and nuclei -substrate contact angle (30-50 degrees) on average particle size have been ascertained. In the case of homogeneous nucleation, the particle size increases with temperature, while pressure has a negligible effect. Further, the particle size decreases when the antisolvent dissolution rate and initial solute loading in solvent are increased. For heterogeneous nucleation, an enhancement in contact angle increases the particle size. These trends are in agreement with the experimental observations reported in the literature. The computational method thus elucidates a generalized approach for engineering desired particle size in subcritical CO2-mediated antisolvent crystallization. (C) 2015 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
机译：目前调查的可调谐性工作antisolvency亚临界二氧化碳的影响(二氧化碳),在丙酮溶液胆固醇,促进高和快速过度饱和生产所需的胆固醇微粒子。对操作条件的选择结果在高固体溶质过度饱和。进一步耦合的计算分析均匀和异相成核晶体生长动力学。进化并验证其一致性预测的粒子大小的比较与实验获得的。压力的影响(60 - 70条),温度(291 - 303 K),最初的溶质浓度(90 - 100%),特定的二氧化碳溶解率(0.095 - -6.0分钟(1)),核基质接触角(30 - 50度)平均粒子尺寸已经确定。均匀成核,粒子的大小有一个与温度增加,而压力可以忽略不计的效果。当antisolvent溶解率降低加载和初始溶质在溶剂增加了。在接触角增加增强粒子的大小。实验观察报道文学。所说的广义的工程方法想要在亚临界CO2-mediated粒度antisolvent结晶。化学工程师学会。爱思唯尔帐面价值保留所有权利。

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