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When CuAAC 'Click Chemistry' goes heterogeneous

机译：当CuAAC“点击化学”异构

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摘要

Within the green chemistry context, heterogeneous catalysis applied to organic synthesis is becoming an increasingly important field, bringing its own innovation and specific properties to organic chemistry. The well known 'click chemistry' is now challenged by this paradigm change and numerous methods involving heterogeneously catalyzed click chemistry have been and are currently being developed. This review covers these developments and shows that various reliable heterogeneous methods, alternative to the commonly used Meldal-Sharpless method, do exist for click chemistry, including those involving flow chemistry, and that they could be applied to a variety of compounds, solving some problems faced by more conventional methods.
机译：在绿色化学的背景下,异构催化应用于有机合成成为一个越来越重要的领域,把自己的创新和具体有机化学性质。“点击化学”是现在的挑战涉及范式变化和众多的方法不同类地催化点击化学是,目前正在开发。综述了这些发展和显示各种异构的方法可靠,选择常用的Meldal-Sharpless点击化学方法,确实存在,包括涉及流化学,他们可以应用于各种各样的化合物,解决传统所面临的一些问题方法。

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