A highly efficient heterogeneous copper-catalyzed three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes

Zhao Hong; He Wen; Wei LiCai Mingzhong

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A highly efficient heterogeneous copper-catalyzed three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes

机译：一种高效异构copper-catalyzed三分量的耦合tetrahydroisoquinolines,醛和1-alkynes

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A highly efficient heterogeneous three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes was achieved in toluene at 70 degrees C in the presence of a 3-(2-aminoethylamino)propyl-functionalized MCM-41-supported copper(I) complex [MCM-41-2N-CuI], yielding a variety of C1-alkynylated tetrahydroisoquinolines (endo-yne-THIQs) in good to excellent yields with high regioselectivity. This heterogeneous copper catalyst can be easily prepared by a simple two-step procedure from commercially available and inexpensive reagents, and recovered by a simple filtration and reused for at least 10 times without any decrease in activity.

机译：一种高效异构三分量耦合tetrahydroisoquinolines醛70年在甲苯和1-alkynes实现度的存在3 - (2-aminoethylamino) propyl-functionalizedMCM-41-supported铜(I)复杂[MCM-41-2N-CuI],产生各种各样的C1-alkynylated tetrahydroisoquinolines收益率(endo-yne-THIQs)“好到极好”高区域选择性。可以很容易地由一个简单的催化剂从商用两步过程和廉价的试剂,和恢复简单的过滤和重用至少10*没有任何减少活动。

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《Catalysis science & technology》 |2016年第5期|1488-1495|共8页
作者
Zhao Hong; He Wen; Wei LiCai Mingzhong;
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作者单位

Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Peoples R China;

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正文语种英语
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Heterogeneous; aldehydes; 1,2,3,4-tetrahydroisoquinoline;

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A highly efficient heterogeneous copper-catalyzed three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes

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