Dysregulation and therapeutic targeting of RNA splicing in cancer

Robert F. Stanley; Omar Abdel-Wahab

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Dysregulation and therapeutic targeting of RNA splicing in cancer

机译：失调和治疗目标的RNA拼接在癌症

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High-throughput sequencing and functional characterization of the cancer transcriptome have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression and, in some cases, generation of novel splicing-derived proteins. Here, we review recent advances in our understanding of aberrant splicing in cancer pathogenesis and present strategies to harness cancer-specific aberrant splicing for therapeutic intent.

机译：高通量测序和功能描述癌症的转录组发现癌症特异性RNA的失调拼接在各种癌症。在癌症基因组RNA的失调因素导致missplicing,剪接alteration-dependent基因表达,在一些情况下,splicing-derived代的小说蛋白质。理解异常剪接的癌症发病机理和现在的策略来利用为治疗癌症特异性异常剪接意图。

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《Nature cancer.》 |2022年第5期|536-546|共11页
作者
Robert F. Stanley; Omar Abdel-Wahab;
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Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial;

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Dysregulation and therapeutic targeting of RNA splicing in cancer

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