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首页> 外文期刊>Nature cancer. >Outcompeting neighbors for intestinal cancer initiation
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Outcompeting neighbors for intestinal cancer initiation

机译：将其他邻居肠道癌症初始化

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摘要

Χntercellular communication is an important feature of multicellular organisms. However, these open avenues of communication can also be used by one set of cells to the detriment of their neighbors, which occurs during the process of cell competition, in which viable cells are eliminated by neighboring, fitter cells because of interactions that take place between them. Χuch of our knowledge on cell competition comes from studies in Drosophila, and the role of this process during mammalian tumor initiation has remained less explored. Χhree papers published this year in Nature now fill this gap by showing that cell competition has a key role in the initiation of intestinal cancer, by facilitating increased colonization of intestinal crypts by intestinal stem cells (ISCs) that contain oncogenic mutations. Notably, cell competition in this setting did not result in apoptosis of the outcompeted wild-type ISCs, but instead resulted in a significant growth disadvantage in the form of attenuation of their stemness properties. This was found to be caused by increased expression and secretion of WNT and BMP pathway ligands by the mutant cells, paving the way for them to thrive and initiate tumors by colonizing the intestinal crypts.
机译：Χntercellular沟通是重要的多细胞生物的特征。这些开放的沟通渠道也可以所使用的一组细胞的损害他们的邻居,这发生在这个过程细胞的竞争中,可行的细胞消除相邻,因为健康细胞他们之间发生的相互作用。Χ排序知识单元的竞争从果蝇的研究,这样的角色在哺乳动物肿瘤起始过程仍然少了。今年在自然界现在通过展示来填补这个空白细胞竞争的一个关键的角色启动肠道癌症,通过促进增加肠隐窝的殖民肠道干细胞(isc)包含致癌突变。此设置不导致的细胞凋亡与野生型isc,而是结果在显著增长不利的形式具备干细胞的衰减特性。被发现是由于增加表达吗和WNT和BMP通路配体的分泌突变细胞,为他们铺平了道路茁壮成长并启动肿瘤通过殖民肠道隐窝。

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