...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature cancer. >Challenges and opportunities in 2021
【24h】

Challenges and opportunities in 2021

机译：2021年挑战和机遇

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Twelve early-career investigators share their thoughts on the challenges faced by their teams and communities during the past year, and look ahead to new opportunities for 2022.Choosing a career in academic research always involves the development of a remarkable capacity to accept challenging situations and adapt to them, whether it is when planning and performing experiments or building novel lines of research as a junior principal investigator (PI). It involves passion, commitment and patience — in all steps of this journey, we grow, learn and evolve. This process of growth and change is not unlike the one observed within tumors, in which the plasticity of tumor and immune cells is a crucial source of heterogeneity underlying the dynamic features of malignancy. Tumor-associated macrophages (TAMs), the most abundant immune cells in nearly all solid cancers, exhibit a beguiling level of versatility. This past year further revealed the layers of complexity underlying TAM heterogeneity, ontogeny and education, which we now appreciate are far from static and orchestrated in a tumor-and tissue-specific manner. TAMs co-evolve with cancer cells often to the advantage of the tumor — all thanks to the tremendous plastic nature of what are, originally, housekeeper cells of organ homeostasis. This hallmark of macrophage biology is now at the core of myeloid checkpoint blockade approaches and the therapeutic potential may be tremendous, although several challenges remain in understanding how to best equip these cells to boost anti-tumor immunity rather than support malignancy.
机译：十二个青年研究人员分享他们对他们的团队所面临的挑战的想法和社区在过去的一年里,看看在2022年的新机遇。从事学术研究总是涉及到接受的非凡能力的发展具有挑战性的情况和适应他们,是否当计划和执行实验或作为一个初级构建小说的研究首席研究员(π)。承诺和耐心——在所有步骤旅程,我们成长,学习和发展。的增长和变化是截然不同观察肿瘤内,可塑性肿瘤和免疫细胞的重要来源异质性基础的动态特性恶性肿瘤。最丰富的免疫细胞在几乎所有固体癌症,展览的水平的多功能性。层底层TAM的复杂性我们的异质性、个体发生和教育现在远非静态和升值在肿瘤和组织策划的方式。肿瘤的优势——都多亏了巨大的塑料的性质是什么,最初,管家的细胞器官体内平衡。现在是骨髓检查点封锁的核心方法和治疗潜在的可能巨大,但仍存在若干挑战了解如何最好地使这些细胞增强抗肿瘤免疫力而不是支持恶性肿瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号