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首页> 外文期刊>Journal of Cellular Physiology >SV40 Infection of Mesenchymal Stromal Cells From Wharton's Jelly Drives the Production of Inflammatory and Tumoral Mediators
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SV40 Infection of Mesenchymal Stromal Cells From Wharton's Jelly Drives the Production of Inflammatory and Tumoral Mediators

机译：SV40感染的间充质基质细胞沃顿商学院的果冻驱动器的生产炎症和Tumoral介质

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摘要

The Mesenchymal Stromal Cells from umbilical cord Wharton's jelly (WJSCs) are a source of cells with high potentiality for the treatment of human immunological disorders. Footprints of the oncogenic viruses Simian Virus 40 (SV40) and JC Virus (JCPyV) have been recently detected in human WJSCs specimens. The aim of this study is to evaluate if WJSCs can be efficiently infected by these Polyomaviruses and if they can potentially exert tumoral activity. Cell culture experiments indicated that WJSCs could sustain both SV40 and JCPyV infections. A transient and lytic replication was observed for JCPyV, while SV40 persistently infected WJSCs over a long period of time, releasing a viral progeny at low titer without evident cytopathic effect (CPE). Considering the association between SV40 and human tumors and the reported ability of the oncogenic viruses to drive the host innate immune response to cell transformation, the expression profile of a large panel of immune mediators was evaluated in supernatants by the Bioplex platform. RANTES, IL-3, MIG, and IL-12p40, involved in chronic inflammation, cells differentiation, and transformation, were constantly measured at high concentration comparing to control. These findings represent a new aspect of SV40 biological activity in the humans, highlighting its interaction with specific host cellular pathways. In view of these results, it seems to be increasingly urgent to consider Polyomaviruses in the management of WJSCs for their safely use as promising therapeutic source. (C) 2016 Wiley Periodicals, Inc.
机译：从脐带间充质基质细胞沃顿商学院的果冻(WJSCs)细胞的来源高潜力的治疗人类免疫失调。致癌病毒猴病毒40 (SV40)和JC病毒(JCPyV)最近发现人类WJSCs标本。评估如果WJSCs可以有效地感染这些多瘤病毒,如果他们能可能发挥tumoral活动。实验表明,WJSCs可以维持JCPyV和SV40感染。JCPyV观察溶解性复制,而SV40感染持续WJSCs长段时间,释放病毒后代在低效价没有明显的细胞病变效应(CPE)。考虑SV40和之间的关系人类肿瘤的报道能力致癌病毒宿主先天免疫应对细胞转换,表达式概要文件的一个大型面板的免疫介质评估在Bioplex上层清液platform .参与慢性炎症、细胞和转换,分化不断地以高浓度比较来控制。SV40生物活性的新方面人类,强调互动特定的宿主细胞通路。结果,它似乎越来越迫切考虑多瘤病毒的管理WJSCs安全地使用是有前途的治疗来源。公司。

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