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Methylated of genes behaving as potential biomarkers in evaluating malignant degree of glioblastoma

机译：行为作为潜在的基因的甲基化生物标志物在评估恶性程度胶质母细胞瘤

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摘要

Abnormal methylation genes usually act as oncogenes or anti-oncogenes in the occurrence and development of tumor, indicating their potential role as biomarkers in the evaluation of malignant tumor. However, the research on methylation's association with glioblastoma was rare. We attempted to figure out whether the methylation of genes could serve as the biomarker in evaluating the malignant degree of GBM. Methylation microarray data of 275 GBM patients have been downloaded from The Cancer Genome Atlas (TCGA) dataset. Logistic regression was used to find the methylated genes associated with the malignant degree of patients with the tumor. Functional enrichment analysis and network analysis were further performed on these selected genes. A total of 668, 412, 470, and 620 genes relevant with the methylation or demethylation were found to be associated with the malignant degree, Grades 1-4 of tumor. The higher the degree of malignant tumor, the higher of its methylation degree of its corresponding genes. GO and KEGG analysis results showed that these methylated genes were enriched in many functions as cell adhesion, abnormal transcription, and cell cycle disorder, etc. Of note, CCL11 and LCN11 were found to be significantly related to the progression of GBM. Critical genes associated with cell cycle as CCL11 and LCN1 may play essential roles in the occurrence, development, and transition of glioblastoma. More research was needed to explore its potential molecular mechanism.
机译：异常甲基化基因通常充当癌基因或抑癌的发生肿瘤的发展,来显示他们的潜力作为生物标志物在恶性的评价肿瘤。与胶质母细胞瘤是罕见的。试图找出是否甲基化的基因可以作为生物标志物评估“绿带运动”的恶性程度。甲基化芯片275 GBM患者的数据从癌症基因组图谱下载呢(TCGA)数据集。找到相关基因甲基化恶性肿瘤患者。功能富集分析和网络分析进一步对这些选择基因。有关甲基化和脱甲基作用被发现与恶性程度,等级1 - 4的肿瘤。程度的恶性肿瘤,其越高甲基化程度的相应的基因。和KEGG分析结果表明,这些甲基化基因在许多功能丰富细胞粘附、异常转录细胞周期紊乱等。LCN11被发现显著相关“绿带运动”的进展。与细胞周期CCL11和LCN1可能玩重要作用的发生,发展,胶质母细胞瘤和过渡。需要探索其潜在的分子机制。

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  • 来源
    《Journal of Cellular Physiology》 |2017年第12期|3622-3630|共9页
  • 作者

    Wen Wan-Shun; Hu Sheng-Li; Ai ZhibingMou LinLu Jing-MinLi Sen;

  • 作者单位

    Southwest Med Univ, Dept Spinal Surg, Affiliated Tradit Chinese Med Hosp, 182 Chunhui Rd, Longmatan;

    Xuzhou Med Univ, Dept Neurol, Peoples Hosp Huaian 2, Affiliated Huaian Hosp Xuzhou, Huaian, Peoples;

    Southwest Med Univ, Dept Ophthalmol, Affiliated Tradit Chinese Med Hosp, Longmatan Dist, LuzhouHubei Univ Med, Dept Neurosurg, Taihe Hosp, Shiyan, Hubei, Peoples R ChinaHubei Univ Med, Dept Neurol, Taihe Hosp, Shiyan, Hubei, Peoples R ChinaHangzhou Med Coll, Dept Rehabil Med, Zhejiang Prov Peoples Hosp, Peoples Hosp, Hangzhou, Zhejiang;

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  • 正文语种 英语
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  • 关键词

    Lipoblastoma; Methylated; MethylationBiological MarkersGlomerular Basement MembraneMessenger RNA;

    机译：Lipoblastoma;甲基化;MethylationBiologicalMarkersGlomerular地下室MembraneMessenger RNA;

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