LIPUS suppressed LPS-induced IL-1 alpha through the inhibition of NF-kappa B nuclear translocation via AT1-PLC beta pathway in MC3T3-E1 cells

Nagao Mayu; Tanabe Natsuko; Manaka SoichiroNaito MasakoSekino JumpeiTakayama TadahiroKawato TakayukiTorigoe GoKato ShunichiroTsukune NaoyaMaeno MasaoSuzuki NaotoSato Shuichi

首页> 外文期刊>Journal of Cellular Physiology >LIPUS suppressed LPS-induced IL-1 alpha through the inhibition of NF-kappa B nuclear translocation via AT1-PLC beta pathway in MC3T3-E1 cells

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LIPUS suppressed LPS-induced IL-1 alpha through the inhibition of NF-kappa B nuclear translocation via AT1-PLC beta pathway in MC3T3-E1 cells

机译：LIPUS抑制LPS-induced il - 1α通过nf -κB核的抑制通过AT1-PLCβ通路易位MC3T3-E1细胞

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摘要

Inflammatory cytokines, interleukin (IL)-1, IL-6, and TNF-alpha, are involved in inflammatory bone diseases such as rheumatoid osteoarthritis and periodontal disease. Particularly, periodontal disease, which destroys alveolar bone, is stimulated by lipopolysaccharide (LPS). Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dental treatments. However, the mechanism underlying effects of LIPUS on LPS-induced inflammatory cytokine are not well understood. We therefore aimed to investigate the role of LIPUS on LPS-induced IL-1 alpha production.

机译：炎性细胞因子、白介素(IL) 1、IL - 6,和tnf参与炎性骨类风湿性关节炎等疾病牙周疾病。疾病,破坏牙槽骨,刺激由脂多糖(LPS)。低强度脉冲超声波(LIPUS)在骨科和牙科骨愈合治疗方法。在LPS-induced LIPUS炎症的影响细胞因子是不清楚。旨在调查LIPUS所扮演的角色LPS-induced il - 1α生产。

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来源
《Journal of Cellular Physiology》 |2017年第12期|3337-3346|共10页
作者
Nagao Mayu; Tanabe Natsuko; Manaka SoichiroNaito MasakoSekino JumpeiTakayama TadahiroKawato TakayukiTorigoe GoKato ShunichiroTsukune NaoyaMaeno MasaoSuzuki NaotoSato Shuichi;
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作者单位

Nihon Univ, Grad Sch Dent, Dent Res Ctr, Div Adv Dent Treatment, Tokyo, Japan;

Nihon Univ, Grad Sch Dent, Dept Biochem, POB 101-8310, Tokyo, Japan;

Nihon Univ, Grad Sch Dent, Dept Periodontol, Tokyo, JapanNihon Univ, Grad Sch Dent, Tokyo, Japan;

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正文语种英语
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关键词
SLC33A1 gene; Phospholipase C beta; Interleukin-1 alphaAGTR1 geneNF-kappa BATM wt Allele;

机译：磷脂酶C beta;白介素- SLC33A1 gene;

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LIPUS suppressed LPS-induced IL-1 alpha through the inhibition of NF-kappa B nuclear translocation via AT1-PLC beta pathway in MC3T3-E1 cells

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