Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

Chen Tong; You Yanan; Jiang HuaWang Zack Z.

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Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

机译：Epithelial-mesenchymal过渡(EMT):一个生物过程的发展,干细胞分化和肿瘤发生

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The lineage transition between epithelium and mesenchyme is a process known as epithelialmesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and diseases, such as cancer invasion and metastasis. The EMT and the reverse process, mesenchymal-epithelial transition (MET), also play important roles in stem cell differentiation and de-differentiation (or reprogramming). In this review, we will discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normal and in diseases. Understanding of EMT and MET may help to identify specific markers to distinguish normal stem cells from cancer stem cells in future.

机译：家族之间的过渡上皮和间质是一个被称为过程epithelialmesenchymal过渡(EMT),极化上皮细胞失去附着力财产和获得间充质细胞表型。EMT经常是一个生物过程参与胚胎发生和疾病,如癌症入侵和转移。反向过程,mesenchymal-epithelial过渡(遇到),也发挥着重要作用干细胞分化和de-differentiation(或改变)。讨论当前EMT的研究进展胚胎发育、细胞分化和重组,和癌症恶化代表模型研究的干细胞生物学在正常和疾病。EMT的理解,可以帮助识别特定的标记来区分正常的干细胞在未来癌症干细胞。

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来源
《Journal of Cellular Physiology》 |2017年第12期|3261-3272|共12页
作者
Chen Tong; You Yanan; Jiang HuaWang Zack Z.;
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作者单位

Johns Hopkins Univ, Sch Med, Div Hematol, 720 Rutland Ave, Baltimore, MD 21205 USA;

Fudan Univ, Huashan Hosp, Dept Hematol, 12 Wulumuqi Middle Rd, Shanghai 200040, Peoples R China;

Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai, Peoples R China;

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正文语种英语
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关键词
reprogramming; Stem Cell Differentiation; Emergency Medical TechniciansNeoplastic Stem CellsStem CellsBiological ProcessNeoplastic Cell Transformationmetastatic cancerEpithelial-Mesenchymal Transition;

机译：重组;干细胞分化;紧急情况医疗TechniciansNeoplastic茎CellsStemCellsBiological ProcessNeoplastic细胞TransformationmetastaticcancerEpithelial-Mesenchymal过渡;

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机译：https://researchopenworld.com/development-of-synthetic-cell-differentiation-agent-formulations-for-the-prevention-and-therapy-of-cancer-via-targeting-of-cancer-stem-cells/#

Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

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