Myocardial proteases and cardiac remodeling

Riaz Sadaf; Zeidan Asad; Mraiche Fatima

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Myocardial proteases and cardiac remodeling

机译：心肌蛋白酶和心脏重塑

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摘要

Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling.

机译：心脏肥大(CH)的特点心肌细胞增大,纤维化和细胞凋亡,是死亡的主要原因之一在全球范围内。进一步研究,仍很有必要调查调解的信号通路CH为了确定新的治疗目标。细胞外基质(ECM)的重构。多个研究表明一个重要的角色半胱氨酸蛋白酶和基质金属蛋白酶(基质金属蛋白酶)改制的心。重点是半胱氨酸cathepins的作用,基质金属蛋白酶在心脏重塑。

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来源
《Journal of Cellular Physiology》 |2017年第12期|3244-3250|共7页
作者
Riaz Sadaf; Zeidan Asad; Mraiche Fatima;
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作者单位

Amer Univ Beirut, Dept Anat Cell Biol & Physiol, Fac Med, Beirut, Lebanon;

Qatar Univ, Coll Pharm, POB 2713, Doha, Qatar;

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原文格式 PDF
正文语种英语
中图分类
关键词
Cathepsins; Heart Failure; Matrix MetalloproteinasesCysteine ProteasesMetalloproteasesHallmarkingExtracellular MatrixHeartRemodelingCause of Death;

机译：组织蛋白酶;心力衰竭;矩阵MetalloproteinasesCysteineMatrixHeartRemodelingCause死亡;

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机译：Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu Yong‐Jian Wang Xin‐Rui Han Xin Wen Lei Li Lan Xu Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557).
8. Retraction: Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF‐κB signalling pathway in rats with myocardial infarction. Dong‐Mei Wu, Yong‐Jian Wang, Xin‐Rui Han, Xin Wen, Lei Li, Lan Xu, Jun Lu and Yuan‐Lin Zheng. J Cell Mol Med. 2018; 22: 3058–3072 (https://doi.org/10.1111/jcmm.13557). [O] . 2021

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Myocardial proteases and cardiac remodeling

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