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首页> 外文期刊>Journal of Cellular Physiology >Ginkgolic Acid Inhibits Invasion and Migration and TGF--Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation
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Ginkgolic Acid Inhibits Invasion and Migration and TGF--Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

机译：银杏酸抑制入侵和迁移TGF -诱导EMT的肺癌细胞

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Epithelial-to-mesenchymal transition (EMT) is a critical cellular phenomenon regulating tumor metastases. In the present study, we investigated whether ginkgolic acid can affect EMT in lung cancer cells and the related underlying mechanism(s) of its actions. We found that ginkgolic acid C15:1 (GA C15:1) inhibited cell proliferation, invasion, and migration in both A549 and H1299 lung cancer cells. GA C15:1 also suppressed the expression of EMT related genes (Fibronectin, Vimentin, N-cadherin, MMP-9, MMP-2, Twist and Snail) and suppressed TGF--induced EMT as assessed by reduced expression of mesenchymal markers (Fibronectin, Vimentin, N-cadherin), MMP-9, MMP-2, Twist and Snail. However, GA C15:1 did not affect the expression of various epithelial marker proteins (Occludin and E-cadherin) in both A549 and H1299 cells. TGF--induced morphologic changes from epithelial to mesenchymal cells and induction of invasion and migration were reversed by GA C15:1. Finally, GA C15:1 not only abrogated basal PI3K/Akt/mTOR signaling cascade, but also reduced TGF--induced phosphorylation of PI3K/Akt/mTOR pathway in lung cancer cells. Overall, these findings suggest that GA C15:1 suppresses lung cancer invasion and migration through the inhibition of PI3K/Akt/mTOR signaling pathway and provide a source of potential therapeutic compounds to control the metastatic dissemination of tumor cells. J. Cell. Physiol. 232: 346-354, 2017. (c) 2016 Wiley Periodicals, Inc.
机译：Epithelial-to-mesenchymal (EMT)是一个过渡关键调节肿瘤细胞的现象转移。银杏酸是否能影响EMT在肺癌细胞和相关的基础机制(s)的行动。银杏酸C15:1 (GA C15:1)抑制细胞在这两方面都扩散、入侵和迁移肺癌A549和H1299细胞。抑制EMT相关基因的表达(纤连蛋白、波形蛋白N-cadherin、MMP-9 MMP-2,扭曲和蜗牛)和抑制TGF -诱导EMT评估的间叶细胞的表达减少标记(纤连蛋白、波形蛋白,N-cadherin),MMP-9 MMP-2,扭曲和蜗牛。不影响不同的表达(Occludin和上皮标记蛋白质在A549和H1299细胞钙粘蛋白)。TGF -诱导上皮细胞形态学的变化间充质细胞和诱导的入侵和迁移被GA C15:1逆转。GA C15:1不仅废除基底PI3K / Akt / mTOR信号级联,也减少了TGF -诱导磷酸化mTOR / PI3K / Akt通路的肺癌细胞。, GA C15:1抑制入侵和肺癌迁移的抑制PI3K / Akt / mTOR信号通路,提供的一个来源潜在的治疗性化合物控制转移性肿瘤细胞的传播。杂志。232:346 - 354年,2017年。期刊、公司。

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