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首页> 外文期刊>Journal of Cellular Physiology >Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?
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Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

机译：胆固醇代谢调节会影响大脑吗功能和行为?

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摘要

Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In recent years, the role of cholesterol in the brain has caught the attention of several research groups since a breakdown of cholesterol metabolism has been associated with different neurodevelopmental and neurodegenerative diseases, and interestingly also with psychiatric conditions. The aim of this review is to summarize the current knowledge about the connection between cholesterol dysregulation and various neurologic and psychiatric disorders based on clinical and preclinical studies. J. Cell. Physiol. 232: 281-286, 2017. (c) 2016 Wiley Periodicals, Inc.
机译：胆固醇是细胞的重要组成部分生理机能。膜和决定了物理和蛋白质的生化特性。中枢神经系统、胆固醇控制突触的形成和功能和支持动作电位的跳跃式传导。近年来,中胆固醇的作用大脑已经注意到了一些研究小组从胆固醇的分解新陈代谢与不同有关神经发育和神经退行性与精神疾病,有趣的是也条件。总结当前的知识胆固醇失调和之间的联系各种神经和精神疾病根据临床和临床前研究。细胞。期刊、公司。

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