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首页> 外文期刊>Journal of Cellular Physiology >In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp
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In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp

机译：在体外和体内分化的祖机械消化后获得的干细胞人牙髓

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摘要

Human population is facing a revolutionary change in the demographic structure with an increasing number of elderly people requiring an unmet need to ensure a smooth aging process and dental care is certainly an important aspect that has to be considered. To date, dentistry has been conservative and the need of transferring the scientific models of regenerative dentistry into clinical practice is becoming a necessity. The aim of this study was to characterize the differentiation commitment (in vitro) and the clinical grafting ability (in vivo) of a population of progenitor stem cells obtained after mechanical digestion of dental pulp with an innovative system recently developed. This approach was successfully used in previous studies to obtain a clinical-grade ready to use dental pulp fragments that could be grafted in autologous tissues to obtain bone. We are thus showing that micro grafts resulting from mechanical digestion contain stem cells with a mesenchymal phenotype, able to differentiate toward different cell types and to generate new bone in patients. We are providing data for the establishment of standardized and routinely oral surgery approaches, having outlined the cellular properties of human stem cells obtained from the dental pulp. This method can represent a valid tool for both regenerative medicine and tissue engineering purposes not only applicable to the cranio-maxillofacial region but, likely, to different bone pathologies for a fastening and healing recovering of patients. J. Cell. Physiol. 232: 548-555, 2017. (c) 2016 Wiley Periodicals, Inc.
机译：人类正面临一场革命性的变化在不断增加的人口结构许多老年人需要一个未满足的需求以确保顺利老化过程和牙科保健当然是一个重要方面,是吗考虑。保守和传输的需要科学的模型再生牙科临床实践正成为一种必需品。本研究的目的是描述分化(体外)和承诺临床移植(体内)的能力祖干细胞获得人口机械消化后的牙髓最近开发的创新系统。在以前的方法成功地使用研究获得clinical-grade可以使用了牙髓可以嫁接的碎片自体组织获得骨。表明微移植导致的机械消化含有干细胞的间叶细胞表型,能够区分对不同的细胞类型和产生新骨的病人。建立标准化和常规口服手术方法,概述了细胞人类干细胞获得的属性牙髓。再生医学和组织的工具不仅适用于工程目的cranio-maxillofacial地区,但可能不同的骨骼紧固和病态治疗康复的病人。232: 548 - 555, 2017。公司。

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