Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease

Piwkowska Agnieszka

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Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease

机译：蛋白激酶G和活性氧的作用物种在足细胞功能的调节健康和疾病

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Podocytes and their foot processes form an important cellular layer of the glomerular barrier involved in the regulation of glomerular permeability. Disturbing the function of podocytes plays a central role in the development of proteinuria in diabetic nephropathy. Retraction of the podocyte foot processes that form slit diaphragms is a common feature of proteinuria; although, the correlation between these events in not well understood. Notably, it is unclear whether podocyte foot processes are able to regulate slit diaphragm permeability and glomerular ultrafiltration. The occurrence of reactive oxygen species generation, insulin resistance, and hyperglycemia characterizes early stages of type 2 diabetes. Protein kinase G type I alpha (PKGI) is an intracellular target for vasorelaxant factors. It is activated in both cGMP-dependent and cGMP-independent manners. Recently, we demonstrated a relationship between oxidative stress, PKGI activation, actin reorganization, and changes in the permeability of the filtration barrier. This review discusses how redox imbalance affects both the activity of PKGI and PKGI-dependent signaling pathways in podocytes. J. Cell. Physiol. 232: 691-697, 2017. (c) 2016 Wiley Periodicals, Inc.

机译：足细胞和形成一个脚进程重要的肾小球的细胞层屏障参与肾小球的规定渗透率。足细胞发展过程中扮演着重要的角色在糖尿病肾病蛋白尿。足细胞的收缩的过程形成狭缝横隔膜是一种常见的特征蛋白尿;这些事件不清楚。还不清楚足细胞足突吗能够调节狭缝隔膜渗透率和肾小球超滤。活性氧生成胰岛素阻力和高血糖早期特征阶段的2型糖尿病。我α(PKGI)是一种胞内的目标vasorelaxant因素。cGMP-dependent cGMP-independent礼仪。最近,我们证明了之间的关系氧化应激,PKGI激活,肌动蛋白重组,渗透率的变化滤过屏障。氧化还原平衡如何影响的活动吗PKGI PKGI-dependent信号通路足细胞。(c) 2016年威利期刊公司。

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《Journal of Cellular Physiology》 |2017年第4期|691-697|共7页
作者
Piwkowska Agnieszka;
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Polish Acad Sci, Mossakowski Med Res Ctr, Lab Mol & Cellular Nephrol, Debinki 7, PL-80211 Gdansk;

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正文语种英语
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Diaphragm; Podocytes; Foot process fusionhealth and diseaseCyclic GMP-Dependent Protein KinasesKidney GlomerulusProteinuriaRegulation (biology)Foot ProcessPermeabilityReactive Oxygen SpeciesFoot;

机译：隔膜,足细胞;脚fusionhealth和过程diseaseCyclic GMP-Dependent蛋白质KinasesKidneyGlomerulusProteinuriaRegulation(生物学)ProcessPermeabilityReactive氧气SpeciesFoot;

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机译：Structure Determination and Mechanistic Insights of: I.Cyanobacteriochrome NpR6012g4 Light Sensor Protein in Phototaxis II.Retinal Degeneration 3 (RD3) Protein in Vision III.Ryanodine Receptor 2 (RyR2) Regulation by Calmodulin (CaM) in Cardiac Function =结构测定和机理洞悉：I.趋光性中的蓝细菌色素NpR6012g4光敏蛋白 II.视觉作用中的视网膜退化蛋白3 III.心脏功能中的钙调蛋白调控兰诺定受体2
4. The role of reactive oxygen species during erythropoiesis: an in vitro model using TF-1 cells. [O] . 2009

机译：The role of reactive oxygen species during erythropoiesis: an in vitro model using TF-1 cells.

Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease

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