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首页> 外文期刊>Journal of Cellular Physiology >Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury
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Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury

机译：神经保护和血脑屏障恢复后,Salubrinal皮质刺受伤

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Following a central nervous system (CNS) injury, restoration of the blood-brain barrier (BBB) integrity is essential for recovering homeostasis. When this process is delayed or impeded, blood substances and cells enter the CNS parenchyma, initiating an additional inflammatory process that extends the initial injury and causes so-called secondary neuronal loss. Astrocytes and profibrotic mesenchymal cells react to the injury and migrate to the lesion site, creating a new glia limitans that restores the BBB. This process is beneficial for the resolution of the inflammation, neuronal survival, and the initiation of the healing process. Salubrinal is a small molecule with neuroprotective properties in different animal models of stroke and trauma to the CNS. Here, we show that salubrinal increased neuronal survival in the neighbourhood of a cerebral cortex stab injury. Moreover, salubrinal reduced cortical blood leakage into the parenchyma of injured animals compared with injured controls. Adjacent to the site of injury, salubrinal induced immunoreactivity for platelet-derived growth factor subunit B (PDGF-B), a specific mitogenic factor for mesenchymal cells. This effect might be responsible for the increased immunoreactivity for fibronectin and the decreased activation of microglia and macrophages in injured mice treated with salubrinal, compared with injured controls. The immunoreactivity for PDGF-B colocalized with neuronal nuclei ( NeuN), suggesting that cortical neurons in the proximity of the injury were the main source of PDGF-B. Our results suggest that after an injury, neurons play an important role in both, the healing process and the restoration of the BBB integrity.
机译：中枢神经系统(CNS)损伤后,恢复血脑屏障(BBB)诚信对恢复至关重要体内平衡。阻碍血液物质和细胞进入中枢神经系统薄壁组织,发起一个额外的炎症过程,初始损伤和扩展了导致所谓的二级神经元丧失。星形胶质细胞和profibrotic间充质细胞损伤和迁移到损伤反应网站,创建一个新的神经胶质limitans恢复BBB。解决炎症、神经生存,起始的愈合的过程。神经保护属性在不同的动物中风和创伤模型到中枢神经系统。表明salubrinal增加神经元的生存大脑皮层附近的刺受伤。血漏的软组织受伤动物而受伤的控制。受伤的网站,salubrinal诱导免疫反应性对血小板源生长因子B亚基(PDGF-B),一个特定的促有丝分裂的因素间充质细胞。负责免疫反应性增加纤连蛋白和激活降低小胶质细胞和巨噬细胞在治疗受伤的老鼠salubrinal,相比之下,受伤的控制。PDGF-B与的免疫反应性神经核(NeuN),表明皮层邻近的神经元损伤的PDGF-B的主要来源。在受伤后,神经元发挥重要作用在两者中,心灵的愈合和恢复BBB的完整性。

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