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首页> 外文期刊>Journal of Cellular Physiology >Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion
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Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion

机译：主要Cilium-Regulated EG-VEGF信号促进滋养层入侵

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摘要

Trophoblast invasion is an important event in embryo implantation and placental development. During these processes, endocrine glandderived vascular endothelial growth factor (EG-VEGF) is the key regulator mediating the crosstalk at the feto-maternal interface. The primary cilium is a cellular antenna receiving environmental signals and is crucial for proper development. However, little is known regarding the role of the primary cilium in early human pregnancy. Here, we demonstrate that EG-VEGF regulates trophoblast cell invasion via primary cilia. We found that EG-VEGF activated ERK1/2 signaling and subsequent upregulation of MMP2 and MMP9, thereby facilitating cell invasion in human trophoblast HTR-8/SVneo cells. Inhibition of ERK1/2 alleviated the expression of MMPs and trophoblast cell invasion after EG-VEGF treatment. In addition, primary cilia were observed in all the trophoblast cell lines tested and, more importantly, in human first-trimester placental tissue. The receptor of EG-VEGF, PROKR1, was detected in primary cilia. Depletion of IFT88, the intraflagellar transporter required for ciliogenesis, inhibited primary cilium growth, thereby ameliorating ERK1/2 activation, MMP upregulation, and trophoblast cell invasion promoted by EG-VEGF. These findings demonstrate a novel function of primary cilia in controlling EG-VEGFregulated trophoblast invasion and reveal the underlying molecular mechanism. (C) 2016 Wiley Periodicals, Inc.
机译：滋养层入侵是一个重要的事件胚胎着床、胎盘发展。在这些过程中,内分泌glandderived血管内皮生长因子(EG-VEGF)监管机构调解的相声的关键feto-maternal接口。手机天线接收环境的信号和适当的发展是至关重要的。关于主要的角色所知甚少纤毛在怀孕早期人类。证明EG-VEGF调节滋养层通过初级纤毛细胞入侵。EG-VEGF ERK1/2信号和随后的激活从而upregulation MMP2和MMP9,促进人类滋养层细胞入侵HTR-8 / SVneo细胞。减轻基质金属蛋白酶的表达和滋养层细胞入侵EG-VEGF治疗后。此外,初级纤毛在所有观察到的滋养层细胞行测试,更多重要的是,人类对于妊娠前三个月的胎盘组织。发现在初级纤毛。所需的intraflagellar运输车ciliogenesis,抑制初级纤毛的增长,从而改善ERK1/2激活,MMPupregulation,滋养层细胞的入侵由EG-VEGF提升。小说在控制初级纤毛的功能EG-VEGFregulated滋养层入侵和揭示潜在的分子机制。威利期刊公司。

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