Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer

Di Benedetto Anna; Mottolese Marcella; Sperati FrancescaErcolani CristianaDi Lauro LuigiPizzuti LauraVici PatriziaTerrenato IreneShaaban Abeer M.Humphries Matthew P.Sundara-Rajan SreekumarBarba MaddalenaSpeirs ValerieDe Maria RuggeroMaugeri-Sacca Marcello

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Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer

机译：联系妳的河马传感器男性乳腺癌的生存状况

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Male breast cancer (MBC) is an uncommon malignancy. We have previously reported that the expression of the Hippo transducers TAZ/YAP and their target CTGF was associated with inferior survival in MBC patients. Preclinical evidence demonstrated that Axl is a transcriptional target of TAZ/YAP. Thus, we herein assessed AXL expression to further investigate the significance of active TAZ/YAP-driven transcription in MBC. For this study, 255 MBC samples represented in tissue microarrays were screened for AXL expression, and 116 patients were included. The association between categorical variables was verified by the Pearson's Chi-squared test of independence (2-tailed) or the Fisher Exact test. The relationship between continuous variables was tested with the Pearson's correlation coefficient. The Kaplan-Meier method was used for estimating survival curves, which were compared by log-rank test. Factors potentially impacting 10-year and overall survival were verified in Cox proportional regression models. AXL was positively associated with the TAZ/CTGF and YAP/CTGF phenotypes (P=0.001 and P=0.002, respectively). Patients with TAZ/CTGF/AXL- or YAP/CTGF/AXL-expressing tumors had inferior survival compared with non-triple-positive patients (log rank P=0.042 and P=0.048, respectively). The variables TAZ/CTGF/AXL and YAP/CTGF/AXL were adverse factors for 10-year survival in the multivariate Cox models (HR 2.31, 95%CI:1.02-5.22, P=0.045, and HR 2.27, 95%CI:1.00-5.13, P=0.050). Nearly comparable results were obtained from multivariate analyses of overall survival. The expression pattern of AXL corroborates the idea of the detrimental role of TAZ/YAP activation in MBC. Overall, Hippo-linked biomarkers deserve increased attention in this rare disease. J. Cell. Physiol. 232: 2246-2252, 2017. (c) 2016 Wiley Periodicals, Inc.

机译：男性乳腺癌(MBC)是一种少见恶性肿瘤。河马传感器小胡子/ YAP和的表情他们的目标CTGF与差有关MBC患者的生存。证明妳是一个转录目标小胡子/狂吠。表达式进一步调查活跃的小胡子/ YAP-driven的重要性在MBC转录。样本在组织微阵列来表示筛查妳的表情,和116名患者被包括在内。验证了分类变量皮尔逊卡方测试的独立性(2-tailed)或Fisher精确检验。连续变量之间的关系皮尔森的相关测试系数。估计生存曲线,进行了比较生存率较。10年期和整体生存在考克斯验证成比例的回归模型。与小胡子/ CTGF和呈正相关YAP / CTGF表型(P = 0.001, P = 0.002,分别)。YAP / CTGF AXL-expressing肿瘤低劣生存与non-triple-positive相比日志等级患者(P = 0.042, P = 0.048,分别)。YAP CTGF /妳是10年期的不利因素生存在多变量Cox模型(HR 2.31,95%置信区间:1.02—-5.22,P = 0.045, 2.27和人力资源,95%置信区间:1.00—-5.13,P = 0.050)。结果从多元分析整体的生存。妳证实有害作用的想法的小胡子在MBC / YAP激活。Hippo-linked生物标志物应该增加注意在这种罕见的疾病。232: 2246 - 2252, 2017。公司。

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来源
《Journal of Cellular Physiology》 |2017年第8期|2246-2252|共7页
作者
Di Benedetto Anna; Mottolese Marcella; Sperati FrancescaErcolani CristianaDi Lauro LuigiPizzuti LauraVici PatriziaTerrenato IreneShaaban Abeer M.Humphries Matthew P.Sundara-Rajan SreekumarBarba MaddalenaSpeirs ValerieDe Maria RuggeroMaugeri-Sacca Marcello;
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作者单位

Univ Leeds, Leeds Inst Canc & Pathol, Wellcome Trust Brenner Bldg, Leeds LS9 7TF, W Yorkshire;

Univ Cattolica Sacro Cuore, Inst Gen Pathol, Rome, Lazio, Italy;

Regina Elena Inst Canc Res, Biostat Sci Direct, Rome, ItalyRegina Elena Inst Canc Res, Div Med Oncol 2, Rome, ItalyRegina Elena Inst Canc Res, Dept Pathol, Rome, ItalyQueen Elizabeth Hosp Birmingham, Dept Histopathol, Birmingham, W Midlands, England;

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正文语种英语
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Male Breast Cancer; MBC; SurvivalTransducerscorrelation coefficient (r);

机译：男性乳房癌症;MBC SurvivalTransducerscorrelation系数(r);

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Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer

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