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首页> 外文期刊>Journal of Cellular Physiology >Uremic Serum Impairs Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stromal Cells
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Uremic Serum Impairs Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stromal Cells

机译：尿毒症血清会损害成骨分化人类骨髓间充质基质细胞

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摘要

Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is characterized by an increased fracture risk. Bone marrow mesenchymal stromal cells (BMSCs) may be involved in the pathogenesis of bone disease and, in view of their promising potential applications in bone tissue engineering, the effect of uremia on BMSCs regenerative potential represents a central issue. The present study evaluated in vitro the effect of a serum pool from hemodialysis patients on BMSCs to observe its influence on osteogenic differentiation. Besides alterations in spatial organization and cytotoxicity along with hyperproliferation, gene expression analysis suggested an impairment in the osteogenic differentiation. More importantly, Receptor activator of nuclear factor kappa-B ligand (RANKL) was upregulated with a mild reduction in osteoprotegerin levels. In summary, uremic environment seems to impair BMSCs osteogenic differentiation. Moreover BMSCs themselves may enhance osteoclastogenesis, feasibly contributing to the altered bone remodeling in CKD-MBD patients. J. Cell. Physiol. 232: 2201-2209, 2017. (c) 2016 Wiley Periodicals, Inc.
机译：慢性肾脏Disease-Mineral和骨骼疾病(CKD-MBD)的特点是增加了骨折风险。细胞(bmsc)可能参与了发病机理骨骼疾病,针对他们的承诺潜在的应用在骨组织工程、bmsc尿毒症的效果再生潜力代表中央问题。血液透析患者血清池的效果综合观察其对成骨的影响分化。组织和细胞毒性增生,基因表达分析建议成骨的的一个障碍分化。kappa-B配体激活的核因素(RANKL)是调节有轻微的减少osteoprotegerin水平。环境似乎损害bmsc成骨分化。加强osteoclastogenesis,轻松做贡献在CKD-MBD改变骨重塑病人。(c) 2016年威利期刊公司。

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