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首页> 外文期刊>Journal of Cellular Physiology >Systemic and Local Adipose Tissue in Knee Osteoarthritis
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Systemic and Local Adipose Tissue in Knee Osteoarthritis

机译：膝盖的全身和局部脂肪组织骨关节炎

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Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the major joint affected. The symptoms of osteoarthritis include limited range of motion, joint swelling, and pain causing disability. There are no disease modifying drugs available, and treatments are mainly focused on pain management. Total knee replacement performed at the end stage of the disease is considered the only cure available. It has been found that obese people have an increased risk to develop not only knee but also hand osteoarthritis. This supports the concept that adipose tissue might be related to osteoarthritis not only through overloading. As matter of fact, obesity induces a low grade systemic inflammatory state characterized by the production and secretion of several adipocytokines that may have a role in osteoarthritis development. Furthermore, hypertension, impaired glucose, and lipid metabolism, which are comorbidities associated with obesity, have been shown to alter the joint tissue homeostasis. Moreover, infrapatellar fat pad in the knee has been demonstrated to be a local source of adipocytokines and potentially contribute to osteoarthritis pathogenesis. Here, we discuss the role of systemic and local adipose tissue in knee osteoarthritis. J. Cell. Physiol. 232: 1971-1978, 2017. (c) 2016 Wiley Periodicals, Inc.
机译：骨关节炎是一种常见的慢性关节疾病影响老年人。共同影响。包括的活动范围有限,关节肿胀,和疼痛导致残疾。修改可用药物和治疗主要集中在疼痛管理。替代的最后阶段执行疾病被认为是唯一可用的治疗方法。有一个已经发现,肥胖的人风险增加发展不仅膝盖也手骨关节炎。脂肪组织可能是相关的骨关节炎不仅通过重载。事实上,肥胖诱发低品位系统性炎症状态的特征生产和分泌的adipocytokines可能有作用骨关节炎的发展。高血压、葡萄糖和脂质新陈代谢,相关的并发症与肥胖,已被证明改变关节组织内稳态。垫在膝盖已经证明是一个当地的adipocytokines和潜在来源导致骨关节炎发病机理。我们将讨论全身和局部脂肪的作用组织在膝骨关节炎。232: 1971 - 1978, 2017。公司。

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