Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells

Kumar Vinit; Bayda Samer; Hadla MohamadCaligiuri IsabellaRusso Spena ConcettaPalazzolo StefanoKempter SusanneCorona GiuseppeToffoli GiuseppeRizzolio Flavio

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Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells

机译：增强化疗Open-Caged的行为DNA@Doxorubicin纳米结构对癌症细胞

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In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers the unique opportunity to overcome these barriers. In particular, in the last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis and ability to deliver drugs to cancer cells. Here, an open-caged pyramidal DNA@Doxorubicin (Py-Doxo) nanostructure was constructed with 10 DNA sequences of 26-28 nucleotides for drug delivery to cancer cells. The synthesized DNA nanostructures are sufficiently stable in biological medium. Py-Doxo exhibited significantly enhanced cytotoxicity of the delivered doxorubicin to breast and liver cancer cells up to twofold compared to free doxorubicin. This study demonstrates the importance of the shape and structure of the designed transporter DNA nanostructures for biomedical applications. J. Cell. Physiol. 230: 106-110, 2016. (c) 2015 Wiley Periodicals, Inc.

机译：在癌症治疗中,必须增加的功效和减少副作用化疗药物。独特的机会来克服这些障碍。在过去的几年里,DNA纳米结构的引起了公众的关注定制合成和生物相容性,容易交付药物对癌细胞的能力。一个open-caged锥体DNA@Doxorubicin (Py-Doxo)纳米结构是以10 DNA给药途径的核苷酸序列癌症细胞。纳米结构足够稳定生物介质。显著增强的细胞毒性阿霉素交付给乳腺癌和肝癌细胞相比,双重的自由阿霉素。这项研究的重要性的形状和结构设计的运输车为生物医学应用DNA纳米结构。j .细胞。威利期刊公司。

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来源
《Journal of Cellular Physiology》 |2016年第1期|106-110|共5页
作者
Kumar Vinit; Bayda Samer; Hadla MohamadCaligiuri IsabellaRusso Spena ConcettaPalazzolo StefanoKempter SusanneCorona GiuseppeToffoli GiuseppeRizzolio Flavio;
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作者单位

Univ Munich, Fac Phys, Munich, Germany;

Natl Canc Inst, Dept Mol Biol & Translat Res, Clin Pharmacol, I-33081 Aviano, PN, Italy;

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原文格式 PDF
正文语种英语
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关键词
Circulating Neoplastic Cells; Drug Liberation; Side Effectcancer cellBreastcancer therapyNanostructureDoxorubicin;

机译：循环肿瘤细胞;药物解放Effectcancer cellBreastcancertherapyNanostructureDoxorubicin;

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Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells

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