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首页> 外文期刊>Journal of Cellular Physiology >Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered
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Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

机译：脂肪酸和乳腺癌:让他们在现场或让他们交付

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摘要

Brisk fatty acid (FA) production by cancer cells is accommodated by the Warburg effect. Most breast and other cancer cell types are addicted to fatty acids (FA), which they require for membrane phospholipid synthesis, signaling purposes, and energy production. Expression of the enzymes required for FA synthesis is closely linked to each of the major classes of signaling molecules that stimulate BC cell proliferation. This review focuses on the regulation of FA synthesis in BC cells, and the impact of FA, or the lack thereof, on the tumor cell phenotype. Given growing awareness of the impact of dietary fat and obesity on BC biology, we will also examine the less-frequently considered notion that, in addition to de novo FA synthesis, the lipolytic uptake of preformed FA may also be an important mechanism of lipid acquisition. Indeed, it appears that cancer cells may exist at different points along a lipogenic-lipolytic axis, and FA uptake could thwart attempts to exploit the strict requirement for FA focused solely on inhibition of de novo FA synthesis. Strategies for clinically targeting FA metabolism will be discussed, and the current status of the medicinal chemistry in this area will be assessed. J. Cell. Physiol. 231: 2128-2141, 2016. (c) 2016 Wiley Periodicals, Inc.
机译：轻快的脂肪酸(FA)生产癌细胞通过Warburg效应。乳腺癌和其他类型的癌症细胞是上瘾的脂肪酸(FA),他们需要的膜磷脂合成、信号的目的,和能源生产。足总合成所需的酶密切与每个信号的主要类公元前分子刺激细胞增殖。本文的重点是足协的规定在公元前细胞合成,FA的影响,或缺乏,肿瘤细胞表型。考虑到饮食的影响越来越引起人们的关注脂肪和肥胖在公元前生物学,我们也会检查较少考虑的概念,除了足协的从头合成分解脂肪的吸收的足总也可能是一个脂质收购的重要机制。看来,癌细胞可能存在沿着lipogenic-lipolytic不同的点轴,足总吸收可能挫败的企图利用FA集中的严格要求完全抑制FA的从头合成。临床策略针对FA新陈代谢将讨论,当前的状态药物化学在这一领域评估。(c) 2016年威利期刊公司。

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