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首页> 外文期刊>Journal of Cellular Physiology >Translocation of Endogenous Danger Signal HMGB1 From Nucleus to Membrane Microvesicles in Macrophages
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Translocation of Endogenous Danger Signal HMGB1 From Nucleus to Membrane Microvesicles in Macrophages

机译：HMGB1易位内生的危险信号从核膜微泡巨噬细胞

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High mobility group box 1 (HMGB1) is a nuclear protein that can be released from activated or dead cells. Extracellular HMGB1 can serve as a "danger signal" and novel cytokine that mediates sterile inflammation. In addition to its soluble form, extracellular HMGB1 can also be carried by membrane microvesicles. However, the cellular mechanisms responsible for nuclear HMGB1 translocation to the plasma membrane and release onto membrane microvesicles have not been investigated. Tobacco smoking is a major cause of sterile inflammation in many diseases. Smoking also increases blood levels of HMGB1. In this study, we found that exposure of macrophages to tobacco smoke extract (TSE) stimulated HMGB1 expression, redistribution, and release into the extracellular milieu both as a soluble molecule and, surprisingly, as a microvesicle-associated form (TSE-MV). Inhibition of chromosome region maintenance-1 (CRM1), a nuclear exporter, attenuated TSE-induced HMGB1 redistribution from the nucleus to the cytoplasm, and then its release on TSE-MVs. Our study demonstrates a novel mechanism for the translocation of nuclear HMGB1 to the plasma membrane, and then its release in a microvesicle-associated form. (C) 2016 Wiley Periodicals, Inc.
机译：高机动组框1 (HMGB1)是一个核蛋白质可以从激活或被释放死细胞。“危险信号”和小说介导的细胞因子无菌炎症。形式,细胞外HMGB1也可以携带的膜微泡。负责核HMGB1机制易位到质膜和释放在膜微泡没有调查。无菌炎症在许多疾病。也会增加血液中HMGB1的水平。研究中,我们发现,暴露的巨噬细胞烟草烟雾中提取(TSE)刺激HMGB1表达式,再分配和释放到细胞外环境既是一种可溶性的分子令人惊讶的是,作为microvesicle-associated表单(TSE-MV)。maintenance-1 (CRM1),核出口国,减毒TSE-induced HMGB1再分配细胞核,细胞质中,那么它的TSE-MVs释放。小说的易位核的机制HMGB1质膜,然后它在microvesicle-associated形式发布。2016年威利期刊、公司。

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