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首页> 外文期刊>Journal of Cellular Physiology >Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways
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Apigenin Reduces Survival of Choriocarcinoma Cells by Inducing Apoptosis via the PI3K/AKT and ERK1/2 MAPK Pathways

机译：芹黄素减少绒毛膜癌的细胞的生存通过PI3K / AKT诱导细胞凋亡和ERK1/2MAPK通路

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摘要

Apigenin is a flavonoid found in parsley, onions, oranges, tea, chamomile, wheat, and sprouts. It has a variety of biological properties including anti-oxidant, anti-mutagenic, anti-carcinogenic, anti-inflammatory, anti-proliferative, and anti-spasmodic effects. Based on epidemiological and case-control studies, apigenin is regarded as a novel chemotherapeutic agent against various cancer types. However, little is known about the effects of apigenin on choriocarcinoma cells. Therefore, we investigated the anti-cancer effects of apigenin on choriocarcinoma cells (JAR and JEG3) in the present study. Apigenin reduced viability and migratory properties, increased apoptosis, and suppressed mitochondrial membrane potential in both the JAR and JEG3 cells. In addition, apigenin predominantly decreased phosphorylation of AKT, P70RSK, and S6 whereas the phosphorylation of ERK1/2 and P90RSK was increased by apigenin treatment of JAR and JEG3 cells in a dose-dependent manner. Moreover, treatment of JAR and JEG3 cells with both apigenin and pharmacological inhibitors of PI3K/AKT (LY294002) and ERK1/2 (U0126) revealed synergistic anti-proliferative effects. Collectively, these results indicated that the apigenin is an invaluable chemopreventive agent that inhibits progression and metastasis of choriocarcinoma cells through regulation of PI3K/AKT and ERK1/2 MAPK signal transduction mechanism. (C) 2016 Wiley Periodicals, Inc.
机译：欧芹芹黄素是一种黄酮类发现,洋葱,柑橘、茶叶、洋甘菊、小麦和豆芽。有各种各样的生物属性包括抗氧化剂,anti-mutagenic,致抗炎、anti-proliferative和anti-spasmodic效果。病例对照研究,芹黄素被认为是小说对各种化学治疗剂癌症类型。芹黄素对绒毛膜癌的细胞的影响。因此,我们调查了抗癌芹黄素对绒毛膜癌的影响细胞(JAR和JEG3)在目前的研究中。可行性和迁移特性,增加了细胞凋亡,抑制线粒体膜JAR和JEG3细胞的潜能。此外,芹黄素主要降低了一种蛋白激酶的磷酸化,P70RSK S6而ERK1/2和P90RSK的磷酸化增加了芹黄素JAR和JEG3待遇细胞剂量依赖性的方式。JAR和JEG3细胞与待遇芹黄素和药理抑制剂PI3K / AKT (LY294002)和ERK1/2 (U0126)显示协同anti-proliferative效果。总的来说,这些结果表明,芹黄素是一种无价的chemopreventive代理抑制的进展和转移绒毛膜癌的细胞通过调节PI3K / AKT和ERK1/2 MAPK信号转导机制。

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