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首页> 外文期刊>Journal of Cellular Physiology >Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions
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Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological Conditions

机译：复杂的基质金属蛋白酶的功能在生理和病理条件

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摘要

Matrix metalloproteinases (MMPs) are a diverse group of proteolytic enzymes and play an important role in the degradation and remodeling of the extracellular matrix (ECM). In normal physiological conditions, MMPs are usually minimally expressed. Despite their low expression, MMPs have been implicated in many cellular processes ranging from embryological development to apoptosis. The activity of MMPs is controlled at three different stages: (1) transcription; (2) zymogen activation; and (3) inhibition of active forms by tissue inhibitor metalloproteinases (TIMPs). They can collectively degrade any component of ECM and basement membrane, and their excessive activity has been linked to numerous pathologies mainly including, but not limited to, tumor invasion and metastasis. The lack of information about several MMPs and the steady stream of new discoveries suggest that there is much more to be studied in this field. In particular, there is a need for controlling their expression in disease states. Various studies over the past 30 years have found that each MMP has a specific mode of activation, action, and inhibition. Drugs specifically targeting individual MMPs could revolutionize the treatment of a great number of health conditions and tremendously reduce their burden. In this review article, we have summarized the recent advances in understanding the role of MMPs in physiological and pathological conditions. (C) 2016 Wiley Periodicals, Inc.
机译：基质金属蛋白酶(MMPs)是不同的组蛋白水解酶和发挥重要作用的退化和重构细胞外基质(ECM)。生理条件下,基质金属蛋白酶通常最低限度的表达。表情,基质金属蛋白酶已经涉及很多细胞过程从胚胎学发展细胞凋亡。控制在三个不同的阶段:(1)转录;通过组织抑制剂的抑制活性形式金属蛋白酶(TIMPs)。降解ECM和地下室的任何组件膜,和他们的过度活动与许多病理主要包括,但不限于,肿瘤入侵转移。基质金属蛋白酶和源源不断的新发现表明有更多的研究这一领域。控制疾病的表达。在过去30年里的各种研究已经发现每个MMP的都有一个特定的激活模式,行动,和抑制。针对个人基质金属蛋白酶可以彻底改变治疗许多疾病和极大的减轻他们的负担。评论文章,我们总结了最近进步在理解中基质金属蛋白酶的作用生理和病理条件。2016年威利期刊、公司。

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