Properties of Adult Lung Stem and Progenitor Cells

Bertoncello Ivan

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Properties of Adult Lung Stem and Progenitor Cells

机译：成人肺干细胞和祖细胞的性质

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The last decade has seen significant progress in understanding the organisation of regenerative cells in the adult lung. Cell-lineage tracing and in vitro clonogenic assays have enabled the identification and characterisation of endogenous lung epithelial stem and progenitor cells. Selective lung injury models, and genetically engineered mice have revealed highly conserved gene networks, factors, signalling pathways, and cellular interactions important in maintaining lung homeostasis and regulating lung regeneration and repair following injury. This review describes the current models of lung epithelial stem and progenitor cell organisation in adult mice, and the impediments encountered in translational studies aiming to identify and characterise their human homologs. (C) 2016 Wiley Periodicals, Inc.

机译：过去的十年里经历了重大进展理解组织再生成人肺细胞。体外单独分析已启用内生的识别和描述肺上皮干细胞和祖细胞。选择性肺损伤模型和基因工程小鼠显示高度保守的基因网络、因素、信号通路和在维持细胞相互作用重要肺内稳态和调节肺再生和修复损伤。描述当前的模型肺上皮在成人干细胞和祖细胞组织老鼠,和遇到的障碍目标识别和转化的研究描述他们的人类同源染色体。期刊、公司。

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来源
《Journal of Cellular Physiology》 |2016年第12期|2582-2589|共8页
作者
Bertoncello Ivan;
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作者单位

Univ Melbourne, Lung Hlth Res Ctr, Dept Pharmacol & Therapeut, Melbourne, Vic 3010, Australia;

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原文格式 PDF
正文语种英语
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关键词
Stems; Wound Healing; AdultsStem CellsLungclonogenic assay;

机译：茎;伤口愈合;AdultsStem CellsLungclonogenic分析;

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机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱
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Properties of Adult Lung Stem and Progenitor Cells

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