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首页> 外文期刊>Journal of Cellular Physiology >Agents Which Inhibit NF-kappa B Signaling Block Spontaneous Contractile Activity and Negatively Influence Survival of Developing Myotubes
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Agents Which Inhibit NF-kappa B Signaling Block Spontaneous Contractile Activity and Negatively Influence Survival of Developing Myotubes

机译：代理的抑制nf -κB信号块自发收缩活动和消极影响生存发展中肌管

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摘要

Inhibiting the NF-kappa B signaling pathway provides morphological and functional benefits for the mdx mouse, a model for Duchenne muscular dystrophy characterized by chronic elevations in the nuclear expression of p65, the transactivating component of the NF-kappa B complex. The purpose of this study was to examine p65 expression in nondystrophic and mdx myotubes using confocal immunofluorescence, and determine whether inhibitors of the NF-kappa B pathway alter myotube development. Primary cultures of nondystrophic and mdx myotubes had identical levels of nuclear and cytosolic p65 expression and exhibited equivalent responses to TNF-alpha, thus excluding the hypothesis that the lack of dystrophin is sufficient to induce increases in NF-kappa B signaling. The NF-kappa B inhibitors pyrrolidine dithiocarbamate (PDTC) and sulfasalazine decreased spontaneous contractile activity and reduced myotube viability in a dose-and time-dependent manner.
机译：抑制nf -κB信号通路提供了形态学和功能的好处mdx的鼠标,杜氏肌的典范萎缩症的特点是慢性海拔核表达p65,nf -κB transactivating组成部分复杂。p65表达式nondystrophic和mdx肌管使用共聚焦免疫荧光,并确定是否nf -κB通路的抑制剂改变肌管的发展。nondystrophic和mdx肌管相同水平的核和胞质p65表达式和等效应对tnf展出,从而排除假设缺乏肌营养不良蛋白能充分诱导增加nf -κB信号。吡咯烷二硫代氨基甲酸(PDTC)和柳氮磺胺吡啶减少自发收缩活动和减少肌管的可行性剂量和时间的方式。

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