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首页> 外文期刊>Journal of Cellular Physiology >High Methionine Diet Poses Cardiac Threat: A Molecular Insight
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High Methionine Diet Poses Cardiac Threat: A Molecular Insight

机译：高蛋氨酸饮食构成心脏的威胁:一个分子的洞察力

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High methionine diet (HMD) for example red meat which includes lamb, beef, pork can pose cardiac threat and vascular dysfunction but the mechanisms are unclear. We hypothesize that a diet rich in methionine can malfunction the cardiovascular system in three ways: (1) by augmenting oxidative stress; (2) by inflammatory manifestations; and (3) by matrix/vascular remodeling. To test this hypothesis we used four groups of mice: (1) WT; (2) WT+methionine; (3) CBS+/-; (4) CBS+/-+methionine. We observed high oxidative stress in mice fed with methionine which was even higher in CBS+/- and CBS+/-+methionine. Higher oxidative stress was indicated by high levels of SOD-1 in methionine fed mouse hearts whereas IL-1, IL-6, TNF, and TLR4 showed high inflammatory manifestations. The upregulated levels of eNOS/iNOS and upregulated levels of MMP2/MMP9 along with high collagen deposition indicated vascular and matrix remodeling in methionine fed mouse. We evaluated the cardiac function which was dysregulated in the mice fed with HMD. These mice had decreased ejection fraction and left ventricular dysfunction which subsequently leads to adverse cardiac remodeling. In conclusion, our study clearly shows that HMD poses a cardiac threat by increasing oxidative stress, inflammatory manifestations, matrix/vascular remodeling, and decreased cardiac function. J. Cell. Physiol. 231: 1554-1561, 2016. (c) 2015 Wiley Periodicals, Inc.
机译：高蛋氨酸饮食(HMD)例如红肉其中包括羊肉、牛肉、猪肉可以构成心脏吗和血管功能障碍,但威胁机制尚不清楚。饮食中富含蛋氨酸可以故障心血管系统在三个方面:(1)增加氧化应激;表现;重构。WT组老鼠:(1);CBS + / -;氧化应激与蛋氨酸老鼠在CBS + / -和更高CBS + / - +蛋氨酸。由高水平的表示SOD-1蛋氨酸美联储的老鼠心脏而il - 1、il - 6、TNF和TLR4显示高炎症表现。以挪士/伊诺和调节调节水平MMP2、MMP9的水平以及较高的胶原蛋白沉积血管和矩阵表示装修在蛋氨酸美联储鼠标。特异表达的心脏功能头盔显示器的老鼠。射血分数、左心室功能障碍,随后导致不良心脏重塑。清楚地表明,HMD构成心脏威胁增加氧化应激,炎症矩阵/血管重建和表现心脏功能下降。231: 1554 - 1561, 2016。公司。

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