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首页> 外文期刊>Journal of Cellular Physiology >MicroRNAs: Modulators of the Ras Oncogenes in Oral Cancer
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MicroRNAs: Modulators of the Ras Oncogenes in Oral Cancer

机译：小分子核糖核酸:Ras致癌基因在口腔的调节器癌症

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摘要

Oral squamous cell carcinoma (OSCC) of the head and neck is one of the six most common cancers in the world. OSCC remains the most common cause of cancer deaths in Asian countries. Conventional treatments for OSCC have not improved the overall 5 years survival and therefore alternative therapeutic targets are often sought. Ras is one of the most frequently deregulated oncogenes in oral cancer. Direct targeting the ras has proven unrealistic and hence, exploring and understanding alternative pathways and/or molecules which regulate ras and its signaling that could pave the way for novel molecular targets and therapy for oral cancer. Recently, microRNAs (miRNAs) have been reported to regulate ras oncogenes in human cancers. In this article, we address the microRNA-mediated regulation of the ras oncogenes in oral cancer. We describe extensively the tumor suppressive and oncogenic roles of miRNAs in regulation of ras oncogenes in OSCC. We also discuss the role of miRNA-mediated ras regulation in therapeutic determination of oral cancer. Complete understanding of the miRNA regulation of ras oncogenes in oral cancer may facilitate to plan better strategies for diagnosis, molecular therapeutic targeting and the overall prognosis of this common and deadly cancer. J. Cell. Physiol. 231: 1424-1431, 2016. (c) 2015 Wiley Periodicals, Inc.
机译：口腔鳞状细胞癌(OSCC)和颈部是六个最常见的癌症之一他的整个世界。在亚洲国家癌症死亡。整体治疗OSCC没有改善5年生存,因此选择治疗靶点往往寻求。最频繁的管制致癌基因口腔癌。不现实的,因此,探索和替代途径和/或理解分子调节ras和它的信号这可能为小说分子铺平道路目标和治疗口腔癌。小分子核糖核酸(microrna)已报告规范ras致癌基因在人类癌症。我们的microRNA-mediated监管ras在口腔癌癌基因。广泛的肿瘤抑制和致癌角色的microrna ras致癌基因的调控OSCC。ras监管治疗的决心口腔癌。监管的ras口腔癌癌基因可能促进计划更好的策略诊断、治疗目标和分子这个共同的整体预后和致命的癌症。(c) 2015年威利期刊公司。

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