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首页> 外文期刊>Journal of Cellular Physiology >The Outflow Pathway: A Tissue With Morphological and Functional Unity
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The Outflow Pathway: A Tissue With Morphological and Functional Unity

机译：外流通道:组织形态和功能的统一

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The trabecular meshwork (TM) plays an important role in high-tension glaucomas. Indeed, the TM is a true organ, through which the aqueous humor flows from the anterior chamber to Schlemm's canal (SC). Until recently, the TM, which is constituted by endothelial-like cells, was described as a kind of passive filter. In reality, it is much more. The cells delineating the structures of the collagen framework of the TM are endowed with a cytoskeleton, and are thus able to change their shape. These cells also have the ability to secrete the extracellular matrix, which expresses proteins and cytokines, and are capable of phagocytosis and autophagy. The cytoskeleton is attached to the nuclear membrane and can, in millionths of a second, send signals to the nucleus in order to alter the expression of genes in an attempt to adapt to biomechanical insult. Oxidative stress, as happens in aging, has a deleterious effect on the TM, leading eventually to cell decay, tissue malfunction, subclinical inflammation, changes in the extracellular matrix and cytoskeleton, altered motility, reduced outflow facility, and (ultimately) increased IOP. TMfailure is the most relevant factor in the cascade of events triggering apoptosis in the inner retinal layers, including ganglion cells. (C) 2016 Wiley Periodicals, Inc.
机译：小梁网(TM)中扮演一个重要的在高压青光眼中的作用。一个真正的器官,房水通过来自前房施莱姆氏运河(SC)。由endothelial-like细胞被描述为一种无源滤波器。现实,得多。胶原蛋白的结构框架TM被赋予一个细胞骨架,因此能够改变他们的形状。分泌细胞外基质的能力,表达蛋白质和细胞因子,是吗吞噬作用和自噬的能力。细胞骨架是依附于核膜,以秒发送信号细胞核以改变表达式为了适应生物力学的基因侮辱。TM的有害影响,导致最终细胞衰变,组织故障,亚临床炎症变化细胞外基质和细胞骨架改变能动性,减少房水流畅(最终)IOP升高。事件的级联的相关因素引发细胞凋亡的视网膜层,包括神经节细胞。期刊、公司。

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