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首页> 外文期刊>Journal of Cellular Physiology >The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex
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The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex

机译：以及交感神经和副交感神经的参与神经炎性反应

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摘要

Production of inflammatory cytokines plays important roles in the response against tissue injury and in host defense. Alterations in the production of inflammatory cytokines may cause local or systemic inflammatory imbalance, culminating in organ failure or lethal systemic inflammation. The cholinergic anti-inflammatory pathway has been implicated as an important mechanism to regulate inflammation of targeted tissue. In this review, we discuss important advances, conflicting and controversial findings regarding the involvement of parasympathetic vagus and sympathetic splenic nerve through acetylcholine (ACh) release and alpha 7 nicotinic acetylcholine receptor (nAChR alpha 7) activation in the spleen. In addition, we address the involvement of cholinergic control of inflammation in other organs innerved by the vagus nerve such as gut, liver, kidney and lung, and independent of parasympathetic innervations such as skin and skeletal muscle. Then, other structures and mechanisms independent of vagus or splenic nerve may be involved in this process, such as local cells and motor neurons producing ACh. Altogether, the convergence of these findings may contribute to current anti-inflammatory strategies involving selective drug-targeting and electrical nerve stimulation. (C) 2016 Wiley Periodicals, Inc.
机译：炎性细胞因子的生产重要的角色对组织反应损伤和在宿主防御。炎性细胞因子可能会导致生产局部或全身性炎症不平衡,最终在器官衰竭或致命的系统性炎症。作为一种重要的途径已经牵涉其中调节炎症机制的目标组织。进步,冲突和争议副交感神经的参与迷走神经和交感神经通过脾乙酰胆碱(ACh)释放和α7烟碱乙酰胆碱受体(乙酰胆α7)激活在脾。胆碱能控制的参与在其他器官刺激神经的炎症迷走神经等肠道、肝脏、肾脏和肺,和独立的副交感神经支配如皮肤和骨骼肌。迷走神经或独立的结构和机制脾神经可能参与了这一过程,如当地细胞和运动神经元产生课时。发现可能导致电流抗炎策略涉及选择性药物的靶向和电神经刺激。(C) 2016年威利期刊公司。

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