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首页> 外文期刊>Journal of Cellular Physiology >microRNA-Mediated Survivin Control of Pluripotency
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microRNA-Mediated Survivin Control of Pluripotency

机译：microRNA-Mediated存活素控制多能性

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Understanding the mechanisms that sustain pluripotency in human embryonic stem cells (hESCs) is an active area of research that may prove useful in regenerative medicine and will provide fundamental information relevant to development and cancer. hESCs and cancer cells share the unique ability to proliferate indefinitely and rapidly. Because the protein survivin is uniquely overexpressed in virtually all human cancers and in hESCs, we sought to investigate its role in supporting the distinctive capabilities of these cell types. Results presented here suggest that survivin contributes to the maintenance of pluripotency and that post-transcriptional control of survivin isoform expression is selectively regulated by microRNAs. miR-203 has been extensively studied in human tumors, but has not been characterized in hESCs. We show that miR-203 expression and activity is consistent with the expression and subcellular localization of survivin isoforms that in turn modulate expression of the Oct4 and Nanog transcription factors to sustain pluripotency. This study contributes to understanding of the complex regulatory mechanisms that govern whether hESCs proliferate or commit to lineages. J. Cell. Physiol. 229: 63-70, 2014. (c) 2014 Wiley Periodicals, Inc.
机译：理解的机制,维持在人类胚胎干细胞多能性(为)是一个活跃的研究领域在再生医学证明有用提供相关基本信息发展和癌症。分享独特的增殖能力无限期地和迅速。生存素是几乎独特的过表达在为所有的人类癌症和,我们寻求在支持它的作用进行调查这些细胞类型的独特功能。这里给出的结果表明,生存素有助于维护多能性和转录后生存素的控制同种型表达式是选择性地规定小分子核糖核酸。在人类肿瘤,但没有特点在为其。活动是与表达和一致亚细胞定位的生存素亚型这反过来调节Oct4和表达式Nanog转录因子来维持多能性。理解复杂的监管机制,决定是否为其增殖或提交血统。63 - 70年,2014年。

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