Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

Garrido Pablo; Osorio Fernando G.; Moran JavierCabello EstefaniaAlonso AnaFreije Jose M. P.Gonzalez Celestino

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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

机译：GLUT4诱发代谢重编程和损失影响乳腺癌细胞的可行性

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Metabolic reprogramming strategies focus on the normalization of metabolism of cancer cells and constitute promising targets for cancer treatment. Here, we demonstrate that the glucose transporter 4 (GLUT4) has a prominent role in basal glucose uptake in MCF7 and MDA-MB-231 breast cancer cells. We show that shRNA-mediated down-regulation of GLUT4 diminishes glucose uptake and induces metabolic reprogramming by reallocating metabolic flux to oxidative phosphorylation. This reallocation is reflected on an increased activity of the mitochondrial oxidation of pyruvate and lower lactate release. Altogether, GLUT4 inhibition compromises cell proliferation and critically affects cell viability under hypoxic conditions, providing proof-of-principle for the feasibility of using pharmacological approaches to inhibit GLUT4 in order to induce metabolic reprogramming in vivo in breast cancer models. J. Cell. Physiol. 229: 191-198, 2014. (c) 2014 Wiley Periodicals, Inc.

机译：集中在代谢重编程策略癌症细胞和代谢正常化构成承诺目标癌症治疗。转运蛋白4 (GLUT4)有突出的作用基葡萄糖吸收MCF7和mda - mb - 231乳腺癌细胞。下调的GLUT4减少葡萄糖吸收和诱发代谢重编程重新分配氧化代谢通量磷酸化。在线粒体活动的增加丙酮酸和乳酸低版本的氧化。总之,细胞GLUT4抑制妥协和严重影响细胞增殖生存在缺氧条件下,提供概念验证使用的可行性药理方法抑制GLUT4在为了引起体内代谢重编程在乳腺癌模型。191 - 198年,2014年。

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《Journal of Cellular Physiology》 |2015年第1期|191-198|共8页
作者
Garrido Pablo; Osorio Fernando G.; Moran JavierCabello EstefaniaAlonso AnaFreije Jose M. P.Gonzalez Celestino;
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作者单位

Univ Oviedo, Inst Univ Oncol, Fac Med, Dept Bioquim Biol & Mol, E-33006 Oviedo, Spain;

Univ Oviedo, Dept Biol Func, Area Fisiol, E-33006 Oviedo, Spain;

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正文语种英语
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Breast Cancer Cell; Viability; Anaerobic conditionsreprogrammingglucose transportcancer therapyMetabolicBreast CancerSLC2A4 Gene;

机译：乳腺癌细胞;可行性;厌氧conditionsreprogrammingglucose transportcancertherapyMetabolicBreast CancerSLC2A4基因;

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Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells

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