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首页> 外文期刊>Journal of Cellular Physiology >Can Brown Fat Win the Battle Against White Fat?
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Can Brown Fat Win the Battle Against White Fat?

机译：褐色脂肪能赢得对抗白色脂肪吗?

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A rapid growth in the overweight and obese population in the last few decades suggest that the current diet, exercise, awareness or drug strategies are still not effectively restraining the obesity epidemic. Obesity results from increased energy intake, and the body's energy balance shifts towards energy abundance. Therefore, current research is focused on developing new strategies aimed at increasing energy expenditure. As a result, brown adipose tissue (BAT) is receiving tremendous attention since the major function of BAT is to dissipate energy as heat. For example, mouse models that have increased BAT activity or increased numbers of brown-like adipocytes within the white adipose tissue (WAT) are lean and protected from obesity. Alternatively, mouse models that lack BAT activity are more susceptible to age and diet-induced obesity. However, a significant loss of BAT mass during the natural growth process in humans has created enormous challenges in effectively utilizing this tissue to increase energy expenditure. New strategies are primarily focused on expanding the BAT mass and/or activating the existing BAT. In this regard, recent finding that expression of early B cell factor-2 (Ebf2) reprograms the white pre-adipocytes into brown adipocytes is a significant break-through in developing BAT-mediated strategies to treat obesity. Here we review the major biological functions of WAT and BAT, which play critical but opposing roles in the energy spectrum, energy storage versus energy expenditure, and we evaluate whether activation and/or expansion of BAT is practically achievable to treat obesity in humans. (C) 2015 Wiley Periodicals, Inc.
机译：超重和肥胖的迅速增长人口在过去几十年里显示当前的饮食,锻炼,意识或药物策略还没有有效地抑制肥胖流行病。能量摄入增加,身体的能量平衡转向能源丰富。因此,当前的研究重点开发新战略旨在增加能量消耗。组织(BAT)受到极大的关注因为蝙蝠的主要功能是消散能量以热能的形式。蝙蝠活动增加或增加数量吗则的白色脂肪细胞内的脂肪组织(窟)精益和防止肥胖。另外,小鼠模型缺乏蝙蝠更容易受到年龄和活动食源性肥胖。蝙蝠的质量自然增长过程中人类创造了巨大的挑战有效地利用这一组织增加能量消耗。专注于扩大蝙蝠和/或质量激活现有的蝙蝠。最近发现早期B细胞的表达因子2 (Ebf2)重组白色pre-adipocytes棕色脂肪细胞是a重大突破在发展中BAT-mediated策略来治疗肥胖。审查的主要生物功能窟蝙蝠,发挥至关重要,但反对的角色能量谱,储能和能量支出,我们评估是否激活和/或扩张的蝙蝠几乎是可以实现的在人类治疗肥胖。期刊、公司。

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