Coalition of Nuclear Receptors in the Nervous System

Foerthmann Benjamin; Aletta John M.; Lee Yu-WeiTerranova ChrisBirkaya BarbaraStachowiak Ewa K.Stachowiak Michal K.Claus Peter

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Coalition of Nuclear Receptors in the Nervous System

机译：联合核受体的神经系统

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A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post-mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non-canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons. (C) 2015 Wiley Periodicals, Inc.

机译：通用信号模块被描述利用纤维母细胞的核形式生长因子受体1 (FGFR1)在中央post-mitotic发展的指导作用神经细胞通过协调一致的基因表达。在本文中,我们详细讨论FGFR1核知识互动的合作伙伴在三个场景:(i)订婚FGFR1的神经干细胞和神经调节分化;中脑的受体Nurr1在发展多巴胺能神经元;FGFR1的下游神经生长的相互作用因子(神经生长因子)信号。证明非规范的多功能性,核酪氨酸激酶信号在不同的神经元细胞分化程序。2015年威利期刊、公司。

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来源
《Journal of Cellular Physiology》 |2015年第12期|2875-2880|共6页
作者
Foerthmann Benjamin; Aletta John M.; Lee Yu-WeiTerranova ChrisBirkaya BarbaraStachowiak Ewa K.Stachowiak Michal K.Claus Peter;
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作者单位

SUNY Buffalo, Dept Pathol & Anat Sci, Western New York Stem Cells Culture & Anal Ctr, Buffalo, NY;

Hannover Med Sch, Dept Neuroanat, D-30625 Hannover, Germany;

CH3 BioSyst LLC, New York State Ctr Bioinformat & Life Sci, Buffalo, NY USA;

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正文语种英语
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关键词
Fibroblast Growth Factor Soluble Receptor 1; Nuclear receptors; Interest groupsNervous SystemStem CellsOrphan receptorsProtein-Tyrosine KinasesNerve Growth FactorNeuronsSignal Transduction;

机译：纤维母细胞生长因子可溶性受体1;groupsNervous核受体;兴趣SystemStem CellsOrphan receptorsProtein-TyrosineKinasesNerve增长FactorNeuronsSignal转导;

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Coalition of Nuclear Receptors in the Nervous System

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