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首页> 外文期刊>Journal of Cellular Physiology >Revisiting Chaos Theorem to Understand the Nature of miRNAs in Response to Drugs of Abuse
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Revisiting Chaos Theorem to Understand the Nature of miRNAs in Response to Drugs of Abuse

机译：回顾混乱定理理解自然滥用药物反应的microrna

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Just like Matryoshka dolls, biological systems follow a hierarchical order that is based on dynamic bidirectional communication among its components. In addition to the convoluted inter-relationships, the complexity of each component spans several folds. Therefore, it becomes rather challenging to investigate phenotypes resulting from these networks as it requires the integration of reductionistic and holistic approaches. One dynamic system is the transcriptome which comprises a variety of RNA species. Some, like microRNAs, have recently received a lot of attention. miRNAs are very pleiotropic and have been considered as therapeutic and diagnostic candidates in the biomedical fields. In this review, we survey miRNA profiles in response to drugs of abuse (DA) using 118 studies. After providing a summary of miRNAs related to substance use disorders (SUD), general patterns of miRNA signatures are compared among studies for single or multiple drugs of abuse. Then, current challenges and drawbacks in the field are discussed. Finally, we provide support for considering miRNAs as a chaotic system in normal versus disrupted states particularly in SUD and propose an integrative approach for studying and analyzing miRNA data. (C) 2015 Wiley Periodicals, Inc.
机译：就像俄罗斯套娃、生物系统遵循一个基于等级秩序动态双向沟通中组件。相互关系的复杂性组件跨越几个折叠。就变得相当具有挑战性的研究表型结果从这些网络需要简化论的整合和全面的方法。转录组由各种各样的RNA物种。收到了很多的关注。多效性的和被认为是治疗和诊断的候选人生物医学领域。microrna的概要针对药物滥用(DA)使用118的研究。microrna与物质使用障碍(SUD),microrna的签名的一般模式进行了比较在单个或多个药物的研究滥用。该领域进行了讨论。支持考虑microrna混乱系统在正常和中断状态尤其是在SUD和提出一个综合研究和分析microrna的数据的方法。(C) 2015年威利期刊公司。

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