...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression
【24h】

Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression

机译：新辅助化疗在乳腺癌患者诱发miR-34a和mir - 122的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. The expression of 188 circulating miRNAs was assessed in the plasma of 25 patients before and after NAC by RT-qPCR. Two miRNAs, miR-34aand miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC. These two chemotherapy-induced miRNAs were further studied in the plasma of 22 patients with adjuvant chemotherapy (AC) as well as in 12 patients who did not receive any chemotherapy. Twenty-five plasma miRNAs were modified by NAC. Among these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer. Furthermore, miR-34a levei was elevated in the remaining tumor tissue after NAC treatment. Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especialiy increased after anthracycline-based chemotherapy. Comparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments. This study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the ants-tumor effects of chemotherapy in breast cancer patients.
机译：小分子核糖核酸(microrna)传播在癌症生物标记,但进行了广泛的研究关于的影响所知甚少抗癌药物的表达水平。本文中,我们描述的修改新辅助后循环microrna概要文件乳腺癌化疗(NAC)。188年循环microrna的表达评估等离子体的25例之前和之后的南汽RT-qPCR。南汽后显著增加,是吗以肿瘤组织之前和之后化疗在7患者病理部分响应(pPR)南汽。化疗所致microrna是进一步研究22的等离子体辅助患者化疗(AC)以及在12个病人没有收到任何化疗。等离子体microrna被NAC修改。microrna miR-34a和mir - 122高调节,尤其是在pPR患者积极的乳腺癌。levei高架在剩下的肿瘤组织NAC治疗后。循环期间miR-34a和mir - 122表达南汽especialiy透露,他们的水平蒽环类化疗后增加。比较后的血浆microrna的概要文件南汽和AC建议化疗所致microrna起源于tumoral和non-tumoral隔间。证明NAC专门诱发microrna的表达在等离子体和肿瘤组织,可能参与了ants-tumor影响化疗的乳腺癌患者。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号