Review: Cell Dynamics in Malignant Pleura! Effusions

ENRICO GIARNIERI; G1ANFRANCO BELLIPANNI; MARCELLA MACALUSO

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Review: Cell Dynamics in Malignant Pleura! Effusions

机译：点评:在恶性胸膜细胞动力学!积液

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Malignant pleura! effusions (HPEs) are a common manifestation found in patients with lung cancer. After cytological and histologica! confirmation of malignancy, talc pleurodesis still remains the treatment of choice in patients with MPEs resistant to chemotherapy. Despite this, primary challenges include reduced quality of life and life expectancy in general. Therefore, a better understanding of the cell biology of MPEs, along with improvements in treatment is greatly needed. It has recently been demonstrated that HPEs may represent an excellent source for identification of molecular mechanisms within the tumor and its environment. The present review summarizes the current understanding of HPEs cells and tumor microenvirortment, and particularly focuses on dissecting the cross-talk between HPEs and epithelial to mesencbymai transition (EMT), inflammation and cancer stem cells.

机译：恶性胸膜!表现在肺癌患者中找到。在细胞学和histologica !恶性肋膜滑石仍然是患者的治疗选择的议员对化疗产生抗药性。挑战包括生活质量和减少一般寿命。了解细胞生物学的议员,以及改善治疗非常必要的。它最近被证明了惠普代表的一个极好来源识别的分子机制及其在肿瘤环境。当前的理解惠普细胞和肿瘤microenvirortment,特别关注解剖和惠普之间的串音上皮mesencbymai过渡(EMT),炎症和癌症干细胞。

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来源
《Journal of Cellular Physiology》 |2015年第2期|272-277|共6页
作者
ENRICO GIARNIERI; G1ANFRANCO BELLIPANNI; MARCELLA MACALUSO;
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作者单位

Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University La;

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原文格式 PDF
正文语种英语
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关键词
cytology; Pleura; EffusionLung CancerHealth-Related Quality Of LifeNeoplastic Stem Cellslife expectancyTumourstalc pleurodesis;

机译：细胞学、胸膜、EffusionLung CancerHealth-RelatedLifeNeoplastic茎Cellslife质量肋膜expectancyTumourstalc;

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Review: Cell Dynamics in Malignant Pleura! Effusions

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