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首页> 外文期刊>Journal of Cellular Physiology >Absence of Bone Sialoprotein (BSP) Alters Profoundly Hematopoiesis and Upregulates Osteopontin
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Absence of Bone Sialoprotein (BSP) Alters Profoundly Hematopoiesis and Upregulates Osteopontin

机译：缺乏骨涎蛋白(BSP)的改变深刻的造血和移植骨桥蛋白

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摘要

Matrix proteins of the SIBLING family interact with bone cells, extracellular matrix and mineral and are thus in a key position to regulate the microenvironment of the bone tissue, including its hematopoietic component. In this respect, osteopontin (OPN) has been implicated in the hematopoietic stem cell (HSC) niche as negative regulator of the HSC function. We investigated the impact on hematopoietic regulation of the absence of the cognate bone sialoprotein (BSP). BSP knockout (-/-) mice display increased bone marrow cellularity, and an altered commitment of hematopoietic precursors to myeloid lineages, leading in particular to an increased frequency of monocyte/macrophage cells. The B cell pool is increased in -/- bone marrow, and its composition is shifted toward more mature lymphocyte stages. BSP-null mice display a decreased HSC fraction among LSK cells and a higher percentage of more committed progenitors as compared to +/+. The fraction of proliferating LSK progenitors is higher in -/- mice, and after PTH treatment the mutant HSC pool is lower than in +/+. Strikingly, circulating levels of OPN as well as its expression in the bone tissue are much higher in the -/-. Thus, a BSP-null bone microenvironment affects the hematopoietic system both quantitatively and qualitatively, in a manner in part opposite to the OPN knockout, suggesting that the effects might in part reflect the higher OPN expression in the absence of BSP. J. Cell. Physiol. 230: 1342-1351, 2015. (c) 2014 Wiley Periodicals, Inc., A Wiley Company
机译：矩阵兄弟家族的蛋白质相互作用骨细胞、细胞外基质和矿物质因此在关键位置调节骨组织的微环境,包括其造血组件。骨桥蛋白(OPN)被卷入造血干细胞(HSC)利基为负监管机构的HSC的功能。对造血调控的影响没有同源骨涎蛋白(BSP)。BSP淘汰赛(- / -)小鼠显示了骨头骨髓细胞结构和承诺的改变髓系造血前体细胞,导致在特定的频率增加单核细胞/巨噬细胞的细胞。增加- / -骨髓,及其组成是转向更成熟淋巴细胞阶段。BSP-null老鼠显示HSC分数下降LSK细胞和更高比例的更多祖细胞+ / +相比。的增殖LSK祖细胞高- / -小鼠,甲状旁腺素治疗后突变是低于+ / + HSC池。OPN水平以及它的传播骨组织中表达更高- / -。影响造血系统定量和定性的方式部分相反OPN淘汰赛,暗示的影响可能在一定程度上反映了更高OPN表达BSP的缺失。杂志。230:1342 - 1351年,2015年。期刊,Inc .威利公司

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