Resveratrol Inhibits NLRP3 Inflammasome Activation by Preserving Mitochondrial Integrity and Augmenting Autophagy

Chang Ya-Ping; Ka Shuk-Man; Hsu Wan-HanChen AnnChao Louis KuopingLin Chai-ChingHsieh Cho-ChenChen Ming-ChengChiu Huan-WenHo Chen-LungChiu Yi-ChichLiu May-LanHua Kuo-Feng

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Resveratrol Inhibits NLRP3 Inflammasome Activation by Preserving Mitochondrial Integrity and Augmenting Autophagy

机译：白藜芦醇抑制NLRP3 Inflammasome激活通过维持线粒体的完整性和增加自噬

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The NLRP3 inflammasome is a caspase-1-containing multi-protein complex that controls the release of IL-1 and plays important roles in the development of inflammatory disease. Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome-derived IL-1 secretion and pyroptosis in macrophages. Resveratrol inhibits the activation step of the NLRP3 inflammasome by suppressing mitochondrial damage. Resveratrol also induces autophagy by activating p38, and macrophages treated with an autophagy inhibitor are resistant to the suppressive effects of resveratrol. In addition, resveratrol administration mitigates glomerular proliferation, glomerular sclerosis, and glomerular inflammation in a mouse model of progressive IgA nephropathy. These findings were associated with decreased renal mononuclear leukocyte infiltration, reduced renal superoxide anion levels, and inhibited renal NLRP3 inflammasome activation. Our data indicate that resveratrol suppresses NLRP3 inflammasome activation by preserving mitochondrial integrity and by augmenting autophagy. J. Cell. Physiol. 230: 1567-1579, 2015. (c) 2014 Wiley Periodicals, Inc., A Wiley Company

机译：的NLRP3 inflammasome caspase-1-containing多复杂的控制释放il - 1和扮演重要的角色炎症性疾病的发展。报告说,白藜芦醇,多酚化合物自然产生的植物,抑制NLRP3inflammasome-derived il - 1的分泌,pyroptosis巨噬细胞。的激活步骤NLRP3 inflammasome抑制线粒体损伤。也引发自噬通过激活p38和巨噬细胞自噬抑制剂的治疗耐药的抑制效应吗白藜芦醇。政府减轻肾小球增生、肾小球硬化和肾小球炎症的小鼠模型进步的IgA肾病。与减少肾单核白细胞浸润,减少肾超氧化物负离子含量,抑制肾NLRP3inflammasome激活。白藜芦醇抑制NLRP3 inflammasome激活通过维持线粒体的完整性通过增加自噬。230: 1567 - 1579, 2015。Inc .威利公司

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《Journal of Cellular Physiology》 |2015年第7期|1567-1579|共13页
作者
Chang Ya-Ping; Ka Shuk-Man; Hsu Wan-HanChen AnnChao Louis KuopingLin Chai-ChingHsieh Cho-ChenChen Ming-ChengChiu Huan-WenHo Chen-LungChiu Yi-ChichLiu May-LanHua Kuo-Feng;
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作者单位

Taiwan Forestry Res Inst, Div Wood Cellulose, Taipei, Taiwan;

Natl Ilan Univ, Dept Biomechatron Engn, Ilan 260, Taiwan;

Natl Ilan Univ, Dept Biotechnol & Anim Sci, Ilan 260, TaiwanChina Med Univ, Dept Cosmeceut, Taichung, TaiwanNatl Def Med Ctr, Grad Inst Life Sci, Taipei, TaiwanToko Univ, Dept Nutr Sci, Chiayi, TaiwanNatl Def Med Ctr, Triserv Gen Hosp, Dept Pathol, Taipei, TaiwanNatl Def Med Ctr, Grad Inst Aerosp & Undersea Med, Taipei, Taiwan;

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正文语种英语
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resveratrol; Interleukin-1; Autophagy;

机译：None;

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机译：Lipopolysaccharide-induced DC-SIGN / TLR4相声activates NLRP3 inflammasomes通过在胃上皮MyD88-independent信号细胞

Resveratrol Inhibits NLRP3 Inflammasome Activation by Preserving Mitochondrial Integrity and Augmenting Autophagy

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