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首页> 外文期刊>Journal of Cellular Physiology >Functional Interaction Between the ESCRT-I Component TSG101 and the HSV-1 Tegument Ubiquitin Specific Protease
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Functional Interaction Between the ESCRT-I Component TSG101 and the HSV-1 Tegument Ubiquitin Specific Protease

机译：功能性ESCRT-I之间的交互组件TSG101和1型单纯疱疹外皮泛素特定的蛋白酶

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摘要

Similar to phosphorylation, transient conjugation of ubiquitin to target proteins (ubiquitination) mediated by the concerted action of ubiquitin ligases and de-ubiquitinating enzymes (DUBs) can affect substrate function. As obligate intracellular parasites, viruses rely on different cellular pathways for their own replication and the well conserved ubiquitin conjugating/de-conjugating system is not an exception. Viruses not only usurp the host proteins involved in the ubiquitination/de-ubiquitination process, but they also encode their own ubiquitin ligases and DUBs. Here we report that an N-terminal variant of the herpes simplex virus (HSV) type-1 large tegument protein VP1/2 (VP1/2(1-767)), encompassing an active DUB domain (herpesvirus tegument ubiquitin specific protease, htUSP), and TSG101, a component of the endosomal sorting complex required for transport (ESCRT)-I, functionally interact. In particular, VP1/2(1-767) modulates TSG101 ubiquitination and influences its intracellular distribution. Given the role played by the ESCRT machinery in crucial steps of both cellular pathways and viral life cycle, the identification of TSG101 as a cellular target for the HSV-1 specific de-ubiquitinating enzyme contributes to the clarification of the still under debate function of viral encoded DUBs highly conserved throughout the Herpesviridae family. J. Cell. Physiol. 230: 1794-1806, 2015. (c) 2014 Wiley Periodicals, Inc.
机译：类似于磷酸化,短暂的结合泛素的目标蛋白(泛素化)由泛素的协调一致的行动连接和de-ubiquitinating酶(配音)影响底物功能。细胞内的寄生虫,病毒依靠不同的细胞通路为他们自己的复制和守恒的泛素接合/ de-conjugating系统不是一个例外。蛋白质参与泛素化/ de-ubiquitination过程,但是他们也自己的泛素连接酶和编码配音。单纯疱疹病毒(HSV)的1型大内膜蛋白VP1/2 (VP1/2 (1 - 767)),包括一个活跃的配音域(疱疹病毒具体外皮泛素蛋白酶,htUSP),TSG101 endosomal排序的一个组成部分复杂的运输所需(ESCRT)我,功能交互。VP1/2(1 - 767)调节TSG101泛素化影响其细胞内的分布。ESCRT机械中所扮演的角色至关重要步骤的细胞通路和病毒的生活周期,TSG101作为细胞的识别目标特定de-ubiquitinating 1型单纯疱疹病毒酶导致的澄清仍在争论病毒编码的配音的函数在整个Herpesviridae高度保守的家庭。(c) 2014年威利期刊公司。

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