TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes

Chen Jicui; Ren Jianmin; Jing QingpingLu SumeiZhang YuchaoLiu YuantaoYu CongGao PengZong ChenLi XiaWang Xiangdong

首页> 外文期刊>Journal of Cellular Physiology >TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes

【24h】

TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes

机译：TSH / TSHR信号抑制脂肪酸合酶(FASN)脂肪细胞中表达

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

TSH/TSHR signaling plays a role in the regulation of lipid metabolism in adipocytes. However, the precise mechanisms are not known. In the present study, we determined the effect of TSH on fatty acid synthase (FASN) expression, and explored the underlying mechanisms. In vitro, TSH reduced FASN expression in both mRNA and protein levels in mature adipocytes and was accompanied by protein kinase A (PKA) activation, cAMP-response element binding protein (CREB) phosphorylation, as well as extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun NH2-terminal kinase (JNK) activation. TSH-induced downregulation of FASN was partially abolished by inhibition of PKA and ERK, but not JNK. TSHR and FASN expression in visceral tissue was significantly increased in C57BL/6 mice with diet-induced obesity compared with control animals, whereas thyroid TSHR expression was normal. These findings suggest that activation of TSHR directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK. In obese animals, this function of TSHR seems to be counteracted. The precise mechanisms need further investigation. J. Cell. Physiol. 230: 2233-2239, 2015. (c) 2015 Wiley Periodicals, Inc.

机译：TSH / TSHR信号在调节过程中发挥作用脂肪细胞的脂质代谢。精确的机制并不清楚。研究中,我们确定了TSH对脂肪的影响酸合成酶(FASN)表达式,并探讨了底层机制。在mRNA和蛋白表达水平成熟的脂肪细胞,并伴有蛋白质激酶(PKA)激活,cAMP-response元素结合蛋白(分子)磷酸化作为细胞外signal-regulated激酶1/2(ERK1/2), and c-Jun NH2-terminal kinase (JNK)激活。部分被抑制的PKA和兵,但不是物。内脏组织显著增加C57BL / 6小鼠食源性肥胖比较控制动物,而甲状腺TSHR表情是正常的。直接抑制FASN TSHR的激活成熟脂肪细胞的表达,可能由PKA的兵。TSHR的功能似乎抵消。精确的机制需要进一步调查。细胞。威利期刊公司。

著录项

来源
《Journal of Cellular Physiology》 |2015年第9期|2233-2239|共7页
作者
Chen Jicui; Ren Jianmin; Jing QingpingLu SumeiZhang YuchaoLiu YuantaoYu CongGao PengZong ChenLi XiaWang Xiangdong;
展开▼
作者单位

Shandong Univ, Hosp 2, Dept Endocrinol, Jinan 250012, Peoples R China;

Shandong Univ, Sch Med, Dept Cell Biol, Jinan 250012, Peoples R China;

Zibo First Hosp, Dept Endocrinol, Zibo, Shandong, Peoples R ChinaShandong Univ, Dept Endocrinol, Qilu Hosp, Jinan 250012, Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Fatty Acid Synthases; Thyrotropin; AdipocytesProtein Kinase ALipid Metabolism;

机译：脂肪酸合成酶;促甲状腺素;AdipocytesProtein激酶ALipid新陈代谢;

相似文献

外文文献
中文文献

1. Saturated Fatty Acid Induces Insulin Resistance Partially Through Nucleotide-binding Oligomerization Domain 1 Signaling Pathway in Adipocytes [J] . Yi-jun Zhou, Yin-si Tang, Yu-ling Song, 中国医学科学杂志（英文版） . 2013,第004期
2. Fatty Acid Synthase and Hormone-sensitive Lipase Expression in Liver Are Involved in Zinc-a2-glycoprotein-induced Body Fat Loss in Obese Mice [J] . Feng-ying Gong, Jie-ying Deng, Hui-juan Zhu, 中国医学科学杂志：英文版 . 2010,第003期
3. Fatty Acid Synthase and Hormone-sensitive Lipase Expression in Liver Are Involved in Zinc-α2-glycoprotein-induced Body Fat Loss in Obese Mice [J] . Feng-ying Gong, Jie-ying Deng, Hui-juan Zhu, 中国医学科学杂志（英文版） . 2010,第003期
4. Identification of a Long-Chain Fatty Acid Elongase from Nannochloropsis sp.Involved in the Biosynthesis of Fatty Acids by Heterologous Expression in Saccharomyces cerevisiae [J] . GUO Minrui, CHEN Guogang, CHEN Jiluan, 中国海洋大学学报（英文版） . 2019,第005期
5. Poultry fat decreased fatty acid transporter protein mRNA expression and affected fatty acid composition in chickens [J] . Jianmin Yuan, Bingkun Zhang, Yuming Guo 畜牧与生物技术杂志(英文版) . 2012,第004期
6. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. [O] . Jeroen P Roose, Maximilian Diehn, Michael G Tomlinson, 2003

机译：T cell receptor-independent basal signaling via Erk and abl kinases suppresses RaG gene expression.

TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes

摘要

著录项

相似文献

相关主题

期刊订阅